My research is interested in the underlying mechanisms of genetic and non-genetic risk factors for disorders, such as trace metal biology, of the Central Nervous System. Zinc and its function at synapses and in intracellular signaling are at the core of my research. Zinc, as an environmental factor taken up by the diet, is also at the center of gut-brain interactions.

My research is particularly captivated by the interplay of non-genetic factors and the CNS in mechanisms such as synapse formation and maturation. The dysregulation of trace metals, a key non-genetic factor, is a recurring theme in many brain disorders. Unraveling their role in modifying synaptic function, especially in the context of diseases triggered by both genetic and environmental components, is a fascinating and pressing area of study.

To investigate the role of genetic and non-genetic factors in disorders of the CNS, I use several approaches. For example, targeted manipulation of biometal levels in animal models and cells derived from human induced pluripotent stem cells is a significant goal in my research. To that end, developing novel drug carriers (i.e., Nanoparticles) and assays designed to evaluate their biological effects, safety, and toxicity has become an essential part of my research. On the other hand, we investigate human patients with selected disorders and perform a state-of-the-art assessment of their cell biology using 3D organoids derived from hIPSC.

By delving into the intricate balance of environmental and genetic factors in trace metal homeostasis, my research aims to pave the way for innovative therapeutic strategies. This, in turn, holds the promise of restoring normal function in individuals grappling with brain disorders, instilling a sense of hope and optimism in the field.

CAREER PROFILE

• 2000-2005  TU Munich, Germany, Diploma in Biology, Major: Genetics, Minor: Neurobiology and Zoology
• 2005-2009   University Ulm, Germany, PhD, international PhD program in molecular medicine