My research is focused on better understanding the epidemiology, risk, clinical outcomes and treatment strategies for Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI).  We are particularly interested in understanding the relationship between AKI, CKD and major clinical outcomes as well as preventive strategies using large national and international data. Using data from the National Health and Examination Surveys (NHANES) and the US Renal Data System (USRDS), we have described the burden and clinical outcomes of several cardiovascular diseases in this vulnerable population. Our group has also advanced our understanding of treatment outcomes in dialysis and optimal dialysis strategies. Specific themes include, cardiovascular diseases and their treatment, mineral bone disease, dialysis strategies, medication prescribing, adherence to clinical guidelines, and gout and hyperuricaemia. Our team at the Graduate Entry Medical School (GEMS) have been awarded two (3-year) HRB grants to study the epidemiology of Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) in the Irish Health System. These studies will also provide a framework for the development of national surveillance systems that can be successfully used to track the burden, clinical outcomes and cost of kidney disease care in the health system.  In support of this initiative, we also work with the HSE in the deployment of national IT system in nephrology which will be used to bolster clinical and epidemiological research in Ireland. Emerging areas of interest include Big Data in health and Connected Health in order to improve health system performance and overall patient outcomes.