Personal profile
Biography
Research Interests
For over 25 years, Evelyn's research interest has been elucidating the role of orphan nuclear receptors in human inflammatory diseases, particularly arthritis, as well as psoriasis, type II diabetes and cancer. Her research focus is strongly translational with an emphasis on understanding pathophysiological mechanisms in human and animal diseases. Ongoing collaborations with clinicians and research scientists, ensures that this basic research is firmly grounded in clinical relevance. This work has been supported with research grant income from EULAR, Health Research Board and Science Foundation Ireland including a Principal Investigator award from 2010-2015. These awards have strengthened research capacity, enhanced interdisciplinary collaboration, and enabled structured career development by directly supporting MSc students, PhD candidates, and Postdoctoral Fellows.
Orcid ID profile
Google Scholar prolife
Teaching Interests
Evelyn is currently lead for UL's Biomedical Science module BM4041. The purpose of this module is to provide students with an overview of the anatomical structures and physiological processes that underlay cell, tissue, and whole system homeostasis. The syllabus covers the histology, physiology and mechanisms to control neural, endocrine and biochemical processes responsible for cell and tissue homeostasis. A key focus of this learning centers on the contribution of homeostatic imbalance(s) that leads to the development of disease(s) including autoimmune disease, inflammatory disorders and pathobiology associated with the biochemistry of metabolic syndromes. Using cell and tissue microscopy, computer based laboratory simulations and virtual reality simulations students examine how the breakdown of cellular and molecular mechanisms leads to the pathogenesis of inflammatory-driven disease(s). Furthermore, the module explores how pathological readouts can be used in diagnosis, design of intervention and in the monitoring of disease remission.
Committed to the concept of research-led teaching, Evelyn strives to communicate her enthusiasm to students in the hope of inspiring intrinsic motivation, autonomous learning and reflective practice. Her teaching philosophy has evolved to incorporate evidence-based learning and she uses annual student feedback and overall class performances in assessments/examinations to continuously modify and improve teaching content and her style of teaching. She uses traditional lectures, small group teaching tutorials, PBL, CAL and practical classes to impart and reinforce important concepts in a variety of different ways. Allied to this, a range of assessment instruments are utilized to encourage the best performance and assist students in achieving their learning outcomes.
Education/Academic qualification
PhD, Galway University
Award Date: 1 Jul 1993
External positions
Associate Professor, University of Limerick
4 Aug 2019 → …
Associate Professor, University College Dublin
1 May 2014 → …
Senior Lecturer, University College Dublin
3 Apr 2007 → …
Lecturer, University College Dublin
4 Aug 2002 → …
Research Lecturer (Rheumatology), University College Dublin
3 Jan 2000 → …
Newman Fellow, University College Dublin
1 Dec 1996 → …
Postdoctoral Fellow, Baylor College of Medicine
14 Jul 1993 → …
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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Collaborations and top research areas from the last five years
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Targeting NR4A Orphan Nuclear Receptors for Novel Drug Development in Melanoma
Rodriguez, E. P., Mooney, R., Wagner, C., Jurutka, P., Murphy , E. P. & Thompson, P., 23 May 2025.Research output: Contribution to conference › Abstract › peer-review
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The NR4A orphan receptor modulator C-DIM12 selectively alters inflammatory mediators in myeloid cell
Aldhafiri, et al., S., Murphy, E. & Crean, D., 2023, In: Receptors. 2, 4, p. 264-283Research output: Contribution to journal › Article › peer-review
Open Access -
NR4A1-3 nuclear receptor activity and immune cell dysregulation in rheumatic diseases
Murphy, E. P. & Crean, D., 22 Jul 2022, In: Frontiers in Medicine. 9, 874182.Research output: Contribution to journal › Review article › peer-review
Open Access -
Protein kinase D, ubiquitin and proteasome pathways are involved in adenosine receptor-stimulated NR4A expression in myeloid cells
Giffney, H. E., Cummins, E. P., Murphy, E. P., Brayden, D. J. & Crean, D., 28 May 2021, In: Biochemical and Biophysical Research Communications. 555, p. 19-25 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting NR4A Nuclear Receptors to Control Stromal Cell Inflammation, Metabolism, Angiogenesis, and Tumorigenesis
Crean, D. & Murphy, E. P., 9 Feb 2021, In: Frontiers in Cell and Developmental Biology. 9, 589770.Research output: Contribution to journal › Review article › peer-review
Open Access
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European Science Foundation peer reviewer (External organisation)
Murphy, E. (Professional Member)
14 Jan 2021 → 14 Jan 2025Activity: Membership › Membership of network
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School of Medicine (Organisational unit)
Murphy, E. (Member)
2020Activity: Membership › Membership of committee
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School of Medicine (Organisational unit)
Murphy, E. (Member)
2020Activity: Membership › Membership of committee
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School of Medicine (Organisational unit)
Murphy, E. (Member)
2020Activity: Membership › Membership of committee
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SoM Assessment and Course Evaluation Committee (External organisation)
Murphy, E. (Member)
2019Activity: Membership › Membership of committee