Dr. John Noone is an Assistant Professor in Sport & Exercise Physiology in the Department of Physical Education and Sport Sciences at the University of Limerick. John graduated with first-class honours BSc. in Sport Science and Health from the School of Health and Human Performance at Dublin City University in 2014. Following positions working within the Baku 2015 Operations Committee (BEGOC) for the Baku 2015 European Games in Azerbaijan and pre-doctoral research studies within the Karolinska Institute in Stockholm, Sweden researching into skeletal muscle circadian rhythm biology, John undertook a PhD funded by the European Space Agency and Enterprise Ireland taking place between Dublin City University’s School of Health and Human Performance and the Life Science Research Facility (formerly the National Institute for Cellular Biotechnology), Ireland focused on undercovering the effects of physical inactivity on skeletal muscle metabolic function. Following award of his PhD in 2021, John was appointed as a postdoctoral research fellow within the research group of Prof. Richard K. Porter at Trinity College Dublin, Ireland's School of Biochemistry and Immunology. Here John investigated the efficacious role of drug treatments within the cannabinoid receptors using in-vitro models of human skeletal muscle cancer cachexia. Following this, John was appointed to his second postdoctoral research fellowship within the research group of Prof. Bret H. Goodpaster at AdventHealth's Translational Research Institute in Orlando, Florida, USA. Here he worked for 3 years as part of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) investigating the impact of endurance and resistance exercise on mitochondrial energetics using both cell and human models. Furthermore, he was a member of the Study of Muscle Mobility and Aging (SOMMA) consortium focused on studying the bioenergetic adaptations of skeletal muscle with aging and its relationship to aerobic capacity.

John’s research interests are focused on the metabolic adaptation of skeletal muscle in response to physical activity and inactivity. John is a member of the Physical Activity for Health (PAfH) research centre within the University of Limerick (https://www.ul.ie/ehs/pafh), the largest physical activity consortium in the world, the Molecular Transducers of Physical Activity consortium (MoTrPAC) (https://www.motrpac.org/), and the Study of Muscle Mobility and Aging (SOMMA) consortium (https://www.sommastudy.com/) within the United States. John’s current work focuses on:

• Understanding how muscle changes as we age by assessing the relationship between maximal aerobic capacity and ex vivo and in vivo mitochondrial bioenergetics in 30-94 years old individuals.
• Comprehending the effect exercise and sedentary behaviour have on the imprinting of in vitro primary skeletal muscle satellite cells from biopsies derived from both highly active and sedentary individuals.
• Adaptation of skeletal muscle mitochondrial bioenergetics to structured resistance/aerobic within ex vivo muscle biopsy specimens.

Expertise: Human metabolic rate measurement at rest and during exercise by indirect calorimetry. Tissue sampling including phlebotomy and skeletal muscle biopsy. High resolution respirometry, fractionation, immunoprecipitation and microscopy of skeletal muscle and tissue culture samples. In vitro cell culture models for metabolic analysis in response to differing conditions such as gene knockout, cancer cachexia, and exercise. Analysis of human and cell culture specimen for enzymatic, protein and gene signaling. Professional: The Physiological Society, International Research Group for Biochemistry of Exercise (IBEC), American College of Sports Medicine (ACSM), European Association for the Study of Diabetes (EASD), Irish Endocrine Society (IES), American Aging Association – FASEB, The Biochemical Society, The Mitochondrial Physiological Society (MiPSoc), European Society for Muscle Research (ESMR). ORCID: https://orcid.org/0000-0002-5733-4816. Researchgate: https://www.researchgate.net/profile/John-Noone.

Dr. John Noone teaches exercise physiology within the Support Systems for Skeletal Muscle Contraction and Nutrition, Exercise Metabolism and Sports Performance modules on the Sport and Exercise Science undergraduate degree program.