My research focuses on understanding the neurobiology of severe mental illnesses. Studies include identifying aberrant ATP use and elucidating dysregulation of intracellular signalling networks in the brain in psychiatric disorders. In addition, research is ongoing to understand the role of the purinergic system in the brain in suicide. This work takes a bidirectional-translational approach, combining findings from postmortem human brain tissues with in vitro models and bioinformatic analyses to offer new insights into the pathophysiology of neuropsychiatric illnesses.