Personal profile
Research Interests
My research focuses on understanding the neurobiology of severe mental illnesses. Studies include identifying aberrant ATP use and elucidating dysregulation of intracellular signalling networks in the brain in psychiatric disorders. In addition, research is ongoing to understand the role of the purinergic system in the brain in suicide. This work takes a bidirectional-translational approach, combining findings from postmortem human brain tissues with in vitro models and bioinformatic analyses to offer new insights into the pathophysiology of neuropsychiatric illnesses.
Education/Academic qualification
PhD, The Molecular, Cellular and Behavioural Effects of Electroconvulsive Stimulation in the Rodent Brain
3 Dec 2007 → 29 Jun 2012
Award Date: 29 Jun 2012
External positions
Adjunct Graduate Faculty , University of Toledo College of Medicine and Life Sciences
19 Oct 2025 → 1 Nov 2028
Assistant Professor, University of Toledo College of Medicine and Life Sciences
1 Aug 2018 → 28 Jun 2024
Postdoctoral Fellow, University of Cincinnati
1 Jul 2014 → 27 Jul 2018
Keywords
- RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Dysregulated Transcript Expression but Not Function of the Glutamate Transporter EAAT2 in the Dorsolateral Prefrontal Cortex in Schizophrenia
O'Donovan, S. M., Shan, D., Wu, X., Choi, J. H. & McCullumsmith, R. E., 1 Mar 2025, In: Schizophrenia bulletin. 51, 2, p. 531-542 12 p.Research output: Contribution to journal › Article › peer-review
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Purinergic System Transcript Changes in the Dorsolateral Prefrontal Cortex in Suicide and Major Depressive Disorder
Sahay, S., Lundh, A. E., Sirole, R. P., McCullumsmith, R. E. & O'Donovan, S. M., Mar 2025, In: International Journal of Molecular Sciences. 26, 5, 1826.Research output: Contribution to journal › Article › peer-review
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Transcriptomic Analysis of the Amygdala in Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder Reveals Differentially Altered Metabolic Pathways
Zhang, X., Valeri, J., Eladawi, M. A., Gisabella, B., Garrett, M. R., Vallender, E. J., McCullumsmith, R., Pantazopoulos, H. & O'Donovan, S. M., 11 Nov 2024, (E-pub ahead of print) In: Schizophrenia Bulletin.Research output: Contribution to journal › Article › peer-review
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Metabolic Insights into Neuropsychiatric Illnesses and Ketogenic Therapies: A Transcriptomic View: A Transcriptomic View
Sahay, S., Pulvender, P., Rami Reddy, M. V. S. R., McCullumsmith, R. E. & O'Donovan, S. M., Aug 2024, In: International Journal of Molecular Sciences. 25, 15, 31 p., 8266.Research output: Contribution to journal › Article › peer-review
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Enhancement of student learning experience: Public Outreach activity using multiple means of engagement (UDL in practice)
Hoffmann Sarda, F. A., O'Donovan, S., McGovern, A. & Ryan, E., 15 Jan 2025, Learning, Teaching and Assessment - Naming, Sharing and Transforming Practice Conference, University of Limerick.Research output: Other contribution › peer-review