Sinead O'Donovan

2025

Dysregulated Transcript Expression but Not Function of the Glutamate Transporter EAAT2 in the Dorsolateral Prefrontal Cortex in Schizophrenia

O'Donovan, S. M., Shan, D., Wu, X., Choi, J. H. & McCullumsmith, R. E., 1 Mar 2025, In: Schizophrenia bulletin. 51, 2, p. 531-542 12 p.

Research output: Contribution to journal › Article › peer-review

Enhancement of student learning experience: Public Outreach activity using multiple means of engagement (UDL in practice)

Hoffmann Sarda, F. A., O'Donovan, S., McGovern, A. & Ryan, E., 15 Jan 2025, Learning, Teaching and Assessment - Naming, Sharing and Transforming Practice Conference, University of Limerick.

Research output: Other contribution › peer-review

Neuronal alterations in AKT isotype expression in schizophrenia

Devine, E. A., Imami, A. S., Eby, H., Sahay, S., Hamoud, A. R., Golchin, H., Ryan, W., Shedroff, E. A., Arvay, T., Joyce, A. W., Asah, S. M., Walss-Bass, C., O’Donovan, S. & McCullumsmith, R. E., Apr 2025, In: Molecular Psychiatry. 30, 4, p. 1573-1584 12 p., e321.

Research output: Contribution to journal › Article › peer-review

2024

Activity of Protein Kinase A in the Frontal Cortex in Schizophrenia

Sahay, S., Henkel, N. D., Vargas, C.F.-A., McCullumsmith, R. E. & O'Donovan, S. M., Jan 2024, In: Brain Sciences. 14, 1, 13.

Research output: Contribution to journal › Article › peer-review

Adenosine Metabolism Pathway Alterations in Frontal Cortical Neurons in Schizophrenia

Sahay, S., Devine, E. A., Vargas, C. F. A., McCullumsmith, R. E. & O’Donovan, S. M., Oct 2024, In: Cells. 13, 19, 1657.

Research output: Contribution to journal › Article › peer-review

Open Access

Adenosine Receptor mRNA Expression in Frontal Cortical Neurons in Schizophrenia

Sahay, S., Devine, E. A., McCullumsmith, R. E. & O'Donovan, S. M., Jan 2024, In: Cells. 13, 1, 32.

Research output: Contribution to journal › Article › peer-review

Differentially Altered Metabolic Pathways in the Amygdala of Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder

Zhang, X., Valeri, J., Eladawi, M. A., Gisabella, B., Garrett, M. R., Vallender, E. J., McCullumsmith, R., Pantazopoulos, H. & O'Donovan, S. M., 19 Apr 2024, In: medRxiv : the preprint server for health sciences.

Research output: Contribution to journal › Article › peer-review

Extracellular matrix abnormalities in the hippocampus of subjects with substance use disorder

Valeri, J., Stiplosek, C., O'Donovan, S. M., Sinclair, D., Grant, K. A., Bollavarapu, R., Platt, D. M., Stockmeier, C. A., Gisabella, B. & Pantazopoulos, H., Dec 2024, In: Translational Psychiatry. 14, 1, p. 115 115.

Research output: Contribution to journal › Article › peer-review

Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice

Chelini, G., Mirzapourdelavar, H., Durning, P., Baidoe-Ansah, D., Sethi, M. K., O'Donovan, S. M., Klengel, T., Balasco, L., Berciu, C., Boyer-Boiteau, A., McCullumsmith, R., Ressler, K. J., Zaia, J., Bozzi, Y., Dityatev, A. & Berretta, S., 28 May 2024, In: Cell Reports. 43, 5, p. 114112 114112.

Research output: Contribution to journal › Article › peer-review

Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases

Hamoud, A. R., Alganem, K., Hanna, S., Morran, M., Henkel, N., Imami, A. S., Ryan, W., Sahay, S., Pulvender, P., Kunch, A., Arvay, T. O., Meller, J., Shukla, R., O’Donovan, S. M. & McCullumsmith, R., Oct 2024, In: Cell Communication and Signaling. 22, 1, 501.

Research output: Contribution to journal › Article › peer-review

Open Access

Metabolic Insights into Neuropsychiatric Illnesses and Ketogenic Therapies: A Transcriptomic View: A Transcriptomic View

Sahay, S., Pulvender, P., Rami Reddy, M. V. S. R., McCullumsmith, R. E. & O'Donovan, S. M., Aug 2024, In: International Journal of Molecular Sciences. 25, 15, 8266.

Research output: Contribution to journal › Article › peer-review

Shared and unique transcriptional changes in the orbitofrontal cortex in psychiatric disorders and suicide

O'Donovan, S. M., Ali, S., Deng, W., Patti, G., Wang, J., Eladawi, M. & Imami, A., 29 Jan 2024, In: Translation: The University of Toledo Journal of Medical Sciences.

Research output: Contribution to journal › Article › peer-review

The Effect of the COVID-19 Pandemic on Mental Health among College Students in the United States

O'Donovan, S. M., Sahay, S., Vargas, C.F.-A., Hoar, S. C. & Choi, J., 31 Jul 2024, In: Translation: The University of Toledo Journal of Medical Sciences. 12, 5

Research output: Contribution to journal › Article › peer-review

Towards Timely Alzheimer's Diagnosis: A Clinical Data-Driven Approach to Biomarker Discovery (P7-9.016)

Sahay, S., Imami, A., Hamoud, A., McCullumsmith, R. & O'Donovan, S., 9 Apr 2024, In: Neurology. 102, 7 1, p. 3375 1 p.

Research output: Contribution to journal › Article › peer-review

2022

A bioinformatic inquiry of the EAAT2 interactome in postmortem and neuropsychiatric datasets

Asah, S. M., Alganem, K., McCullumsmith, R. E. & O'Donovan, S. M., Nov 2022, In: Schizophrenia Research. 249, p. 38-46 9 p.

Research output: Contribution to journal › Article › peer-review

Adenosine, Schizophrenia and Cancer: Does the Purinergic System Offer a Pathway to Treatment?

Hamoud, A.-R., Bach, K., Kakrecha, O., Henkel, N., Wu, X., McCullumsmith, R. E. & O'Donovan, S. M., 5 Oct 2022, In: International Journal of Molecular Sciences. 23, 19, 11835.

Research output: Contribution to journal › Review article › peer-review

Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder

Valeri, J., O'Donovan, S. M., Wang, W., Sinclair, D., Bollavarapu, R., Gisabella, B., Platt, D., Stockmeier, C. & Pantazopoulos, H., 7 Sep 2022, In: Frontiers in Neuroscience. 16, p. 903941 903941.

Research output: Contribution to journal › Article › peer-review

Altered purinergic receptor expression in the frontal cortex in schizophrenia

Alnafisah, R., Lundh, A., Asah, S. M., Hoeflinger, J., Wolfinger, A., Hamoud, A.-R., McCullumsmith, R. E. & O'Donovan, S. M., Dec 2022, In: Schizophrenia (Heidelberg, Germany). 8, 1, p. 96 96.

Research output: Contribution to journal › Article › peer-review

Assessing the effects of antipsychotic medications on schizophrenia functional analysis: a postmortem proteome study

Alnafisah, R. S., Reigle, J., Eladawi, M. A., O'Donovan, S. M., Funk, A. J., Meller, J., Mccullumsmith, R. E. & Shukla, R., Nov 2022, In: Neuropsychopharmacology. 47, 12, p. 2033-2041 9 p.

Research output: Contribution to journal › Article › peer-review

Editorial overview: Neuroscience: Advances in the field

O'Donovan, S. M., McCullumsmith, R. & Shukla, R., Feb 2022, In: Current opinion in pharmacology. 62, p. 82-84 3 p.

Research output: Contribution to journal › Article

Gene Enrichment Analysis of Astrocyte Subtypes in Psychiatric Disorders and Psychotropic Medication Datasets

Zhang, X., Wolfinger, A., Wu, X., Alnafisah, R., Imami, A., Hamoud, A.-R., Lundh, A., Parpura, V., McCullumsmith, R. E., Shukla, R. & O'Donovan, S. M., 21 Oct 2022, In: Cells. 11, 20, 3315.

Research output: Contribution to journal › Article › peer-review

Schizophrenia: a disorder of broken brain bioenergetics

Henkel, N. D., Wu, X., O'Donovan, S. M., Devine, E. A., Jiron, J. M., Rowland, L. M., Sarnyai, Z., Ramsey, A. J., Wen, Z., Hahn, M. K. & McCullumsmith, R. E., May 2022, In: Molecular Psychiatry. 27, 5, p. 2393-2404 12 p.

Research output: Contribution to journal › Review article › peer-review

The active kinome: The modern view of how active protein kinase networks fit in biological research

Alganem, K., Hamoud, A.-R., Creeden, J. F., Henkel, N. D., Imami, A. S., Joyce, A. W., Ryan V, W. G., Rethman, J. B., Shukla, R., O'Donovan, S. M., Meller, J. & McCullumsmith, R., Feb 2022, In: Current opinion in pharmacology. 62, p. 117-129 13 p.

Research output: Contribution to journal › Review article › peer-review

2021

Activation of acid-sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation

Lin, B., Alganem, K., O'Donovan, S. M., Jin, Z., Naghavi, F., Miller, O. A., Ortyl, T. C., Ruan, Y. C., McCullumsmith, R. E. & Du, J., Dec 2021, In: Molecular Brain. 14, 1, p. 78 78.

Research output: Contribution to journal › Article › peer-review

Astrocytes in Neuropsychiatric Disorders: A Review of Postmortem Evidence

Zhang, X., Alnafisah, R. S., Hamoud, A.-R. A., Shukla, R., McCullumsmith, R. E. & O'Donovan, S. M., 2021, In: Advances in neurobiology. 26, p. 153-172 20 p.

Research output: Contribution to journal › Review article

Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter

Bentea, E., Villers, A., Moore, C., Funk, A. J., O'Donovan, S. M., Verbruggen, L., Lara, O., Janssen, P., De Pauw, L., Declerck, N. B., DePasquale, E. A. K., Churchill, M. J., Sato, H., Hermans, E., Arckens, L., Meshul, C. K., Ris, L., McCullumsmith, R. E. & Massie, A., Sep 2021, In: Molecular Psychiatry. 26, 9, p. 4754-4769 16 p.

Research output: Contribution to journal › Article › peer-review

Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection

Creeden, J. F., Imami, A. S., Eby, H. M., Gillman, C., Becker, K. N., Reigle, J., Andari, E., Pan, Z. K., O'Donovan, S. M., McCullumsmith, R. E. & McCullumsmith, C. B., Jun 2021, In: Biomedicine and Pharmacotherapy. 138, p. 111437 111437.

Research output: Contribution to journal › Article › peer-review

Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach

O'Donovan, S. M., Imami, A. S., Eby, H., Henkel, N. D., Creeden, J. F., Asah, S. M., Zhang, X., Wu, X., Alnafisah, R., Taylor, R. T., Reigle, J., Thorman, A., Shamsaei, B., Meller, J. & McCullumsmith, R. E., Dec 2021, In: Scientific Reports. 11, 1, p. 4495 4495.

Research output: Contribution to journal › Article › peer-review

KEOPS complex expression in the frontal cortex in major depression and schizophrenia

Abel, M. E., Zhang, X., Asah, S. M., Wolfinger, A., McCullumsmith, R. E. & O'Donovan, S. M., Jul 2021, In: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 22, 6, p. 446-455 10 p.

Research output: Contribution to journal › Article › peer-review

Role of Astrocytes in Major Neuropsychiatric Disorders

Zhang, X., Alnafisah, R. S., Hamoud, A.-R. A., Shukla, R., Wen, Z., McCullumsmith, R. E. & O'Donovan, S. M., Oct 2021, In: Neurochemical Research. 46, 10, p. 2715-2730 16 p.

Research output: Contribution to journal › Review article › peer-review

Strategies to identify candidate repurposable drugs: COVID-19 treatment as a case example

Imami, A. S., McCullumsmith, R. E. & O'Donovan, S. M., Dec 2021, In: Translational Psychiatry. 11, 1, p. 591 591.

Research output: Contribution to journal › Review article › peer-review

2020

Adenosine Kinase Expression in the Frontal Cortex in Schizophrenia

Moody, C. L., Funk, A. J., Devine, E., Devore Homan, R. C., Boison, D., McCullumsmith, R. E. & O'Donovan, S. M., 10 Apr 2020, In: Schizophrenia bulletin. 46, 3, p. 690-698 9 p.

Research output: Contribution to journal › Article › peer-review

Oxytocin's anti-inflammatory and proimmune functions in COVID-19: a transcriptomic signature-based approach

Imami, A. S., O'Donovan, S. M., Creeden, J. F., Wu, X., Eby, H., McCullumsmith, C. B., Uvnäs-Moberg, K., McCullumsmith, R. E. & Andari, E., 1 Sep 2020, In: Physiological genomics. 52, 9, p. 401-407 7 p.

Research output: Contribution to journal › Article › peer-review

2019

Connectivity Analyses of Bioenergetic Changes in Schizophrenia: Identification of Novel Treatments

Sullivan, C. R., Mielnik, C. A., O'Donovan, S. M., Funk, A. J., Bentea, E., DePasquale, E. A., Alganem, K., Wen, Z., Haroutunian, V., Katsel, P., Ramsey, A. J., Meller, J. & McCullumsmith, R. E., 1 Jun 2019, In: Molecular Neurobiology. 56, 6, p. 4492-4517 26 p.

Research output: Contribution to journal › Article › peer-review

Kinase Network Activity Changes in the Frontal Cortex in Depressed-Suicide Subjects

O'Donovan, S., Bentea, E., Alganem, K. & McCullumsmith, R., 1 Dec 2019, In: Neuropsychopharmacology. 44, Suppl 1

Research output: Contribution to journal › Meeting Abstract

Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia

Bentea, E., Depasquale, E. A. K., O'Donovan, S. M., Sullivan, C. R., Simmons, M., Meador-Woodruff, J. H., Zhou, Y., Xu, C., Bai, B., Peng, J., Song, H., Ming, G.-L., Meller, J., Wen, Z. & McCullumsmith, R. E., 10 Jun 2019, In: Molecular omics. 15, 3, p. 173-188 16 p.

Research output: Contribution to journal › Article › peer-review

Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia

Sullivan, C. R., Mielnik, C. A., Funk, A., O'Donovan, S. M., Bentea, E., Pletnikov, M., Ramsey, A. J., Wen, Z., Rowland, L. M. & McCullumsmith, R. E., 1 Dec 2019, In: Scientific Reports. 9, 1, p. 5087 5087.

Research output: Contribution to journal › Article › peer-review

Neuron-specific deficits of bioenergetic processes in the dorsolateral prefrontal cortex in schizophrenia

Sullivan, C. R., Koene, R. H., Hasselfeld, K., O'Donovan, S. M., Ramsey, A. & McCullumsmith, R. E., 1 Sep 2019, In: Molecular Psychiatry. 24, 9, p. 1319-1328 10 p.

Research output: Contribution to journal › Article › peer-review

T84. Characterizing Signal Transduction Networks in Postmortem Depressed-Suicide Subjects

O'Donovan, S., Bentea, E., Alganem, K. & McCullumsmith, R., 15 May 2019, In: Biological Psychiatry. 85, 10_S161

Research output: Contribution to journal › Meeting Abstract

2018

Cell-subtype-specific changes in adenosine pathways in schizophrenia

O'Donovan, S. M., Sullivan, C., Koene, R., Devine, E., Hasselfeld, K., Moody, C. L. & McCullumsmith, R. E., 1 Jul 2018, In: Neuropsychopharmacology. 43, 8, p. 1667-1674 8 p.

Research output: Contribution to journal › Article › peer-review

Defects in Bioenergetic Coupling in Schizophrenia

Sullivan, C. R., O'Donovan, S. M., McCullumsmith, R. E. & Ramsey, A., 1 May 2018, In: Biological Psychiatry. 83, 9, p. 739-750 12 p.

Research output: Contribution to journal › Review article › peer-review

Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia

O'Donovan, S. M., Franco-Villanueva, A., Ghisays, V., Caldwell, J. L., Haroutunian, V., Privette Vinnedge, L. M., McCullumsmith, R. E. & Solomon, M. B., Dec 2018, In: Schizophrenia Research. 202, p. 188-194 7 p.

Research output: Contribution to journal › Article › peer-review

2017

Abnormalities of signal transduction networks in chronic schizophrenia

McGuire, J. L., Depasquale, E. A., Funk, A. J., O'Donnovan, S. M., Hasselfeld, K., Marwaha, S., Hammond, J. H., Hartounian, V., Meador-Woodruff, J. H., Meller, J. & McCullumsmith, R. E., 1 Dec 2017, In: NPJ schizophrenia. 3, 1, p. 30 30.

Research output: Contribution to journal › Article › peer-review

Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression

LaCrosse, A. L., O'Donovan, S. M., Sepulveda-Orengo, M. T., McCullumsmith, R. E., Reissner, K. J., Schwendt, M. & Knackstedt, L. A., 14 Jun 2017, In: Journal of Neuroscience. 37, 24, p. 5809-5821 13 p.

Research output: Contribution to journal › Article › peer-review

Sinead O'Donovan

Research output

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