This award addressed psychobiological mechanisms that may contribute to increased vulnerability to depression in younger females, with a focus on inflammatory processes and reward-related functioning. Inflammatory processes had been implicated in reward-related functioning in women, though potential differences across menopausal status were unclear. The project examined whether inflammation-related effects on reward-related functioning differed between premenopausal and postmenopausal women, using a controlled inflammatory challenge and assessments of immune and reward-related responses.