TY - GEN
T1 - 466729 investigation of phase separation phenomena in a supersaturated ternary amorphous solid dispersion
AU - Kelly, Catherine B.
AU - Albadarin, Ahmad B.
AU - Walker, Gavin M.
N1 - Publisher Copyright:
© American Institute of Chemical Engineers. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Many new chemical entities (NCEs) are failing to progress through drug-development pipelines due to a display of insufficient bioavailability, stemming from the extremely low aqueous solubility properties of many of these materials. The overwhelming majority of these NCEs are small-molecule, crystalline solids so lend themselves to formulation in the higher solubility but thermodynamically unstable amorphous form. A common approach to the formulation of amorphous APIs is through the use of an amorphous solid dispersion. In order to stabilise the thermodynamically unstable amorphous form an excipient to which the API exhibits an affinity through molecular interactions is added during formulation.
AB - Many new chemical entities (NCEs) are failing to progress through drug-development pipelines due to a display of insufficient bioavailability, stemming from the extremely low aqueous solubility properties of many of these materials. The overwhelming majority of these NCEs are small-molecule, crystalline solids so lend themselves to formulation in the higher solubility but thermodynamically unstable amorphous form. A common approach to the formulation of amorphous APIs is through the use of an amorphous solid dispersion. In order to stabilise the thermodynamically unstable amorphous form an excipient to which the API exhibits an affinity through molecular interactions is added during formulation.
UR - http://www.scopus.com/inward/record.url?scp=85019018738&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85019018738
T3 - Particle Technology Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting
SP - 423
EP - 425
BT - Particle Technology Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting
PB - AIChE
T2 - Particle Technology Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting
Y2 - 13 November 2016 through 18 November 2016
ER -