466729 investigation of phase separation phenomena in a supersaturated ternary amorphous solid dispersion

Catherine B. Kelly, Ahmad B. Albadarin, Gavin M. Walker

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Many new chemical entities (NCEs) are failing to progress through drug-development pipelines due to a display of insufficient bioavailability, stemming from the extremely low aqueous solubility properties of many of these materials. The overwhelming majority of these NCEs are small-molecule, crystalline solids so lend themselves to formulation in the higher solubility but thermodynamically unstable amorphous form. A common approach to the formulation of amorphous APIs is through the use of an amorphous solid dispersion. In order to stabilise the thermodynamically unstable amorphous form an excipient to which the API exhibits an affinity through molecular interactions is added during formulation.

Original languageEnglish
Title of host publicationParticle Technology Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting
PublisherAIChE
Pages423-425
Number of pages3
ISBN (Electronic)9781510834446
Publication statusPublished - 2016
EventParticle Technology Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting - San Francisco, United States
Duration: 13 Nov 201618 Nov 2016

Publication series

NameParticle Technology Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting

Conference

ConferenceParticle Technology Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting
Country/TerritoryUnited States
CitySan Francisco
Period13/11/1618/11/16

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