A comparative study of the use of powder X-ray diffraction, Raman and near infrared spectroscopy for quantification of binary polymorphic mixtures of piracetam

Denise M. Croker, Michelle C. Hennigan, Anthony Maher, Yun Hu, Alan G. Ryder, Benjamin K. Hodnett

Research output: Contribution to journalArticlepeer-review

Abstract

Diffraction and spectroscopic methods were evaluated for quantitative analysis of binary powder mixtures of FII(6.403) and FIII(6.525) piracetam. The two polymorphs of piracetam could be distinguished using powder X-ray diffraction (PXRD), Raman and near-infrared (NIR) spectroscopy. The results demonstrated that Raman and NIR spectroscopy are most suitable for quantitative analysis of this polymorphic mixture. When the spectra are treated with the combination of multiplicative scatter correction (MSC) and second derivative data pretreatments, the partial least squared (PLS) regression model gave a root mean square error of calibration (RMSEC) of 0.94 and 0.99%, respectively. FIII(6.525) demonstrated some preferred orientation in PXRD analysis, making PXRD the least preferred method of quantification.

Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume63
DOIs
Publication statusPublished - 7 Apr 2012

Keywords

  • Near-infrared spectroscopy
  • Piracetam polymorphs
  • Powder X-ray diffraction
  • Quantitative analysis
  • Raman spectroscopy

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