TY - JOUR
T1 - A comparative study of the use of powder X-ray diffraction, Raman and near infrared spectroscopy for quantification of binary polymorphic mixtures of piracetam
AU - Croker, Denise M.
AU - Hennigan, Michelle C.
AU - Maher, Anthony
AU - Hu, Yun
AU - Ryder, Alan G.
AU - Hodnett, Benjamin K.
N1 - Copyright © 2012 Elsevier B.V. All rights reserved.
PY - 2012/4/7
Y1 - 2012/4/7
N2 - Diffraction and spectroscopic methods were evaluated for quantitative analysis of binary powder mixtures of FII(6.403) and FIII(6.525) piracetam. The two polymorphs of piracetam could be distinguished using powder X-ray diffraction (PXRD), Raman and near-infrared (NIR) spectroscopy. The results demonstrated that Raman and NIR spectroscopy are most suitable for quantitative analysis of this polymorphic mixture. When the spectra are treated with the combination of multiplicative scatter correction (MSC) and second derivative data pretreatments, the partial least squared (PLS) regression model gave a root mean square error of calibration (RMSEC) of 0.94 and 0.99%, respectively. FIII(6.525) demonstrated some preferred orientation in PXRD analysis, making PXRD the least preferred method of quantification.
AB - Diffraction and spectroscopic methods were evaluated for quantitative analysis of binary powder mixtures of FII(6.403) and FIII(6.525) piracetam. The two polymorphs of piracetam could be distinguished using powder X-ray diffraction (PXRD), Raman and near-infrared (NIR) spectroscopy. The results demonstrated that Raman and NIR spectroscopy are most suitable for quantitative analysis of this polymorphic mixture. When the spectra are treated with the combination of multiplicative scatter correction (MSC) and second derivative data pretreatments, the partial least squared (PLS) regression model gave a root mean square error of calibration (RMSEC) of 0.94 and 0.99%, respectively. FIII(6.525) demonstrated some preferred orientation in PXRD analysis, making PXRD the least preferred method of quantification.
KW - Near-infrared spectroscopy
KW - Piracetam polymorphs
KW - Powder X-ray diffraction
KW - Quantitative analysis
KW - Raman spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=84862811224&partnerID=8YFLogxK
U2 - 10.1016/j.jpba.2012.01.013
DO - 10.1016/j.jpba.2012.01.013
M3 - Article
C2 - 22333478
AN - SCOPUS:84862811224
SN - 0731-7085
VL - 63
SP - 80
EP - 86
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
ER -