TY - GEN
T1 - A computational analysis of a combined cooling anti-solvent continuous crystallization cascade
T2 - Pharmaceutical Discovery, Development and Manufacturing Forum 2014 - Core Programming Area at the 2014 AIChE Annual Meeting
AU - Hutton, Kieran
AU - Frawley, Patrick
PY - 2014
Y1 - 2014
N2 - Presented here are the results of computational investigations into the performance of a two tank continuous crystallization cascade. The system of interest is a combined cooling, anti-solvent crystallization of Paracetamol from methanol and water. The kinetic parameters used in the model were obtained from isolated cooling and anti-solvent batch experiments. The input parameters of interest here are the feed mass flow rate, relative sizes of the two tanks and the distribution of anti-solvent and feed across the tanks. Preliminary findings indicate that the distribution of feed and anti-solvent across the cascade has some impact on the solute recovery but the largest response is seen in the particle size distribution. The maximisation of recovery is generally seen where all feed is directed to the first tank and a portion of the anti-solvent is directed to the first tanks with the remainder directed to the second tank. For each configuration (flow rate and volume) there exists an optimum distribution of streams to maximise recovery and/or to target a particular particle size.
AB - Presented here are the results of computational investigations into the performance of a two tank continuous crystallization cascade. The system of interest is a combined cooling, anti-solvent crystallization of Paracetamol from methanol and water. The kinetic parameters used in the model were obtained from isolated cooling and anti-solvent batch experiments. The input parameters of interest here are the feed mass flow rate, relative sizes of the two tanks and the distribution of anti-solvent and feed across the tanks. Preliminary findings indicate that the distribution of feed and anti-solvent across the cascade has some impact on the solute recovery but the largest response is seen in the particle size distribution. The maximisation of recovery is generally seen where all feed is directed to the first tank and a portion of the anti-solvent is directed to the first tanks with the remainder directed to the second tank. For each configuration (flow rate and volume) there exists an optimum distribution of streams to maximise recovery and/or to target a particular particle size.
UR - http://www.scopus.com/inward/record.url?scp=84957935653&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84957935653
T3 - Pharmaceutical Discovery, Development and Manufacturing Forum 2014 - Core Programming Area at the 2014 AIChE Annual Meeting
SP - 114
EP - 125
BT - Pharmaceutical Discovery, Development and Manufacturing Forum 2014 - Core Programming Area at the 2014 AIChE Annual Meeting
PB - AIChE
Y2 - 16 November 2014 through 21 November 2014
ER -