Abstract
We develop a nonlinear delay-differential equation for the human cardiovascular control system, and use it to explore blood pressure and heart rate variability under short-term baroreflex control. The model incorporates an intrinsically stable heart rate in the absence of nervous control, and allows us to compare the baroreflex influence on heart rate and peripheral resistance. Analytical simplifications of the model allow a general investigation of the rôles played by gain and delay, and the effects of ageing.
| Original language | English |
|---|---|
| Pages (from-to) | 508-526 |
| Number of pages | 19 |
| Journal | Journal of Mathematical Biology |
| Volume | 51 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 2005 |
| Externally published | Yes |
Keywords
- Ageing
- Baroreflex control
- Cardiovascular
- Delay differential equation
- Heart rate variability
- Hypertension
- Mathematical model
- Mayer waves