TY - JOUR
T1 - A Mixed-Crystal Lanthanide Zeolite-like Metal-Organic Framework as a Fluorescent Indicator for Lysophosphatidic Acid, a Cancer Biomarker
AU - Zhang, Shi Yuan
AU - Shi, Wei
AU - Cheng, Peng
AU - Zaworotko, Michael J.
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/9/30
Y1 - 2015/9/30
N2 - Two lanthanide zeolite-like metal-organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb3+ and Eu3+ ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4-43.3 μM). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA.
AB - Two lanthanide zeolite-like metal-organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb3+ and Eu3+ ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4-43.3 μM). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA.
UR - http://www.scopus.com/inward/record.url?scp=84942922643&partnerID=8YFLogxK
U2 - 10.1021/jacs.5b06929
DO - 10.1021/jacs.5b06929
M3 - Article
C2 - 26355993
AN - SCOPUS:84942922643
SN - 0002-7863
VL - 137
SP - 12203
EP - 12206
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 38
ER -