A Mixed-Crystal Lanthanide Zeolite-like Metal-Organic Framework as a Fluorescent Indicator for Lysophosphatidic Acid, a Cancer Biomarker

Shi Yuan Zhang; Wei Shi; Peng Cheng; Michael J. Zaworotko

doi:10.1021/jacs.5b06929

A Mixed-Crystal Lanthanide Zeolite-like Metal-Organic Framework as a Fluorescent Indicator for Lysophosphatidic Acid, a Cancer Biomarker

Shi Yuan Zhang
, Wei Shi
, Peng Cheng
, Michael J. Zaworotko

Nankai University
University of Limerick

Research output: Contribution to journal › Article › peer-review

Abstract

Two lanthanide zeolite-like metal-organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb³⁺ and Eu³⁺ ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4-43.3 μM). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA.

Original language	English
Pages (from-to)	12203-12206
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	137
Issue number	38
DOIs	https://doi.org/10.1021/jacs.5b06929
Publication status	Published - 30 Sept 2015

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10.1021/jacs.5b06929

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title = "A Mixed-Crystal Lanthanide Zeolite-like Metal-Organic Framework as a Fluorescent Indicator for Lysophosphatidic Acid, a Cancer Biomarker",

abstract = "Two lanthanide zeolite-like metal-organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb3+ and Eu3+ ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4-43.3 μM). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA.",

author = "Zhang, \{Shi Yuan\} and Wei Shi and Peng Cheng and Zaworotko, \{Michael J.\}",

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doi = "10.1021/jacs.5b06929",

language = "English",

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AU - Zhang, Shi Yuan

AU - Shi, Wei

AU - Cheng, Peng

AU - Zaworotko, Michael J.

PY - 2015/9/30

Y1 - 2015/9/30

N2 - Two lanthanide zeolite-like metal-organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb3+ and Eu3+ ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4-43.3 μM). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA.

AB - Two lanthanide zeolite-like metal-organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb3+ and Eu3+ ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4-43.3 μM). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA.

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SN - 0002-7863

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ER -

A Mixed-Crystal Lanthanide Zeolite-like Metal-Organic Framework as a Fluorescent Indicator for Lysophosphatidic Acid, a Cancer Biomarker

Abstract

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