A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers

Aideen C. Allen; Siobhan Kelly; Sharee A. Basdeo; Katie Kinsella; Keith J. Mulready; Kingston Hg Mills; Niall Tubridy; Cathal Walsh; Jennifer J. Brady; Michael Hutchinson; Jean M. Fletcher

doi:10.1177/1352458512442992

A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers

Aideen C. Allen, Siobhan Kelly, Sharee A. Basdeo, Katie Kinsella, Keith J. Mulready, Kingston Hg Mills, Niall Tubridy, Cathal Walsh, Jennifer J. Brady, Michael Hutchinson, Jean M. Fletcher

Research output: Contribution to journal › Article › peer-review

Abstract

Although vitamin D deficiency is considered an environmental factor in multiple sclerosis (MS), the immunological and clinical effects of vitamin D supplementation remain unclear. We performed a pilot study of the immunomodulatory effects of vitamin D in healthy individuals (n=4), who took 5000-10,000 IU/day of vitamin D over 15 weeks. After 15 weeks of vitamin D supplementation, serum 25(OH) vitamin D levels rose significantly from baseline, with a corresponding increase in IL-10 production by peripheral blood mononuclear cells and a reduced frequency of Th17 cells. These data provide a strong rationale for randomised trials to assess the clinical effects of vitamin D supplementation in MS.

Original language	English
Pages (from-to)	1797-1800
Number of pages	4
Journal	Multiple Sclerosis
Volume	18
Issue number	12
DOIs	https://doi.org/10.1177/1352458512442992
Publication status	Published - Dec 2012
Externally published	Yes

Keywords

disease modifying therapies
immunology
multiple sclerosis

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title = "A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers",

abstract = "Although vitamin D deficiency is considered an environmental factor in multiple sclerosis (MS), the immunological and clinical effects of vitamin D supplementation remain unclear. We performed a pilot study of the immunomodulatory effects of vitamin D in healthy individuals (n=4), who took 5000-10,000 IU/day of vitamin D over 15 weeks. After 15 weeks of vitamin D supplementation, serum 25(OH) vitamin D levels rose significantly from baseline, with a corresponding increase in IL-10 production by peripheral blood mononuclear cells and a reduced frequency of Th17 cells. These data provide a strong rationale for randomised trials to assess the clinical effects of vitamin D supplementation in MS.",

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AU - Allen, Aideen C.

AU - Kelly, Siobhan

AU - Basdeo, Sharee A.

AU - Kinsella, Katie

AU - Mulready, Keith J.

AU - Mills, Kingston Hg

AU - Tubridy, Niall

AU - Walsh, Cathal

AU - Brady, Jennifer J.

AU - Hutchinson, Michael

AU - Fletcher, Jean M.

PY - 2012/12

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AB - Although vitamin D deficiency is considered an environmental factor in multiple sclerosis (MS), the immunological and clinical effects of vitamin D supplementation remain unclear. We performed a pilot study of the immunomodulatory effects of vitamin D in healthy individuals (n=4), who took 5000-10,000 IU/day of vitamin D over 15 weeks. After 15 weeks of vitamin D supplementation, serum 25(OH) vitamin D levels rose significantly from baseline, with a corresponding increase in IL-10 production by peripheral blood mononuclear cells and a reduced frequency of Th17 cells. These data provide a strong rationale for randomised trials to assess the clinical effects of vitamin D supplementation in MS.

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A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers

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