TY - JOUR
T1 - Acoustic radiation force impulse imaging on ex vivo abdominal aortic aneurysm model
AU - Tierney, Áine P.
AU - Dumont, Douglas M.
AU - Callanan, Anthony
AU - Trahey, Gregg E.
AU - McGloughlin, Timothy M.
N1 - Copyright 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
PY - 2010/5
Y1 - 2010/5
N2 - A method for reliable, noninvasive estimation of abdominal aortic aneurysms (AAA) wall mechanics may be a useful clinical tool for rupture prediction. An in vitro AAA model was developed from an excised porcine aorta with elastase treatment. The AAA model behaviour was analysed using acoustic radiation force impulse (ARFI) imaging techniques to generate and measure wave propagation in both aneurysmal and normal aortic tissue. Opening angle measurement showed a fourfold decrease from healthy aorta to AAA model and pathologic analysis verified this elastin degradation. Maximum wave velocity at 180 mm Hg was 7 mm/ms for healthy tissue and 8.26 mm/ms for the aneurysmal tissue. The mechanical changes produced in the artificially induced aneurysm were found to be detectable using ARFI imaging. (E-mail: [email protected]).
AB - A method for reliable, noninvasive estimation of abdominal aortic aneurysms (AAA) wall mechanics may be a useful clinical tool for rupture prediction. An in vitro AAA model was developed from an excised porcine aorta with elastase treatment. The AAA model behaviour was analysed using acoustic radiation force impulse (ARFI) imaging techniques to generate and measure wave propagation in both aneurysmal and normal aortic tissue. Opening angle measurement showed a fourfold decrease from healthy aorta to AAA model and pathologic analysis verified this elastin degradation. Maximum wave velocity at 180 mm Hg was 7 mm/ms for healthy tissue and 8.26 mm/ms for the aneurysmal tissue. The mechanical changes produced in the artificially induced aneurysm were found to be detectable using ARFI imaging. (E-mail: [email protected]).
KW - Abdominal aortic aneurysms
KW - Acoustic radiation force impulse (ARFI) imaging
KW - In vitro AAA model
KW - Radiation force
UR - http://www.scopus.com/inward/record.url?scp=77952322169&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2010.02.018
DO - 10.1016/j.ultrasmedbio.2010.02.018
M3 - Article
C2 - 20381946
AN - SCOPUS:77952322169
SN - 0301-5629
VL - 36
SP - 821
EP - 832
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 5
ER -