Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing

Ping Zhang; Nopphon Weeranoppanant; Dale A. Thomas; Kohei Tahara; Torsten Stelzer; Mary Grace Russell; Marcus O'Mahony; Allan S. Myerson; Hongkun Lin; Liam P. Kelly; Klavs F. Jensen; Timothy F. Jamison; Chunhui Dai; Yuqing Cui; Naomi Briggs; Rachel L. Beingessner; Andrea Adamo

doi:10.1002/chem.201706004

Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing

Ping Zhang
, Nopphon Weeranoppanant
, Dale A. Thomas
, Kohei Tahara
, Torsten Stelzer
, Mary Grace Russell
, Marcus O'Mahony
, Allan S. Myerson
, Hongkun Lin
, Liam P. Kelly
, Klavs F. Jensen
, Timothy F. Jamison
, Chunhui Dai
, Yuqing Cui
, Naomi Briggs
, Rachel L. Beingessner
, Andrea Adamo

Novartis USA
Burapha University
Massachusetts Institute of Technology
Gifu Pharmaceutical University
University of Puerto Rico
Vertex Pharmaceuticals, Inc.

Research output: Contribution to journal › Article › peer-review

Abstract

As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time-scale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technology, herein we report a second-generation, reconfigurable and 25 % smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand-alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards.

Original language	English
Pages (from-to)	2776-2784
Number of pages	9
Journal	Chemistry - A European Journal
Volume	24
Issue number	11
DOIs	https://doi.org/10.1002/chem.201706004
Publication status	Published - 21 Feb 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Keywords

active pharmaceutical ingredients
continuous flow chemistry
industrial chemistry
synthetic methods

Access to Document

10.1002/chem.201706004

Cite this

Zhang, P., Weeranoppanant, N., Thomas, D. A., Tahara, K., Stelzer, T., Russell, M. G., O'Mahony, M., Myerson, A. S., Lin, H., Kelly, L. P., Jensen, K. F., Jamison, T. F., Dai, C., Cui, Y., Briggs, N., Beingessner, R. L., & Adamo, A. (2018). Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing. Chemistry - A European Journal, 24(11), 2776-2784. https://doi.org/10.1002/chem.201706004

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title = "Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing",

abstract = "As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time-scale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technology, herein we report a second-generation, reconfigurable and 25 \% smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand-alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards.",

keywords = "active pharmaceutical ingredients, continuous flow chemistry, industrial chemistry, synthetic methods",

author = "Ping Zhang and Nopphon Weeranoppanant and Thomas, \{Dale A.\} and Kohei Tahara and Torsten Stelzer and Russell, \{Mary Grace\} and Marcus O'Mahony and Myerson, \{Allan S.\} and Hongkun Lin and Kelly, \{Liam P.\} and Jensen, \{Klavs F.\} and Jamison, \{Timothy F.\} and Chunhui Dai and Yuqing Cui and Naomi Briggs and Beingessner, \{Rachel L.\} and Andrea Adamo",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2018",

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day = "21",

doi = "10.1002/chem.201706004",

language = "English",

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Zhang, P, Weeranoppanant, N, Thomas, DA, Tahara, K, Stelzer, T, Russell, MG, O'Mahony, M, Myerson, AS, Lin, H, Kelly, LP, Jensen, KF, Jamison, TF, Dai, C, Cui, Y, Briggs, N, Beingessner, RL & Adamo, A 2018, 'Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing', Chemistry - A European Journal, vol. 24, no. 11, pp. 2776-2784. https://doi.org/10.1002/chem.201706004

TY - JOUR

T1 - Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing

AU - Zhang, Ping

AU - Weeranoppanant, Nopphon

AU - Thomas, Dale A.

AU - Tahara, Kohei

AU - Stelzer, Torsten

AU - Russell, Mary Grace

AU - O'Mahony, Marcus

AU - Myerson, Allan S.

AU - Lin, Hongkun

AU - Kelly, Liam P.

AU - Jensen, Klavs F.

AU - Jamison, Timothy F.

AU - Dai, Chunhui

AU - Cui, Yuqing

AU - Briggs, Naomi

AU - Beingessner, Rachel L.

AU - Adamo, Andrea

PY - 2018/2/21

Y1 - 2018/2/21

N2 - As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time-scale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technology, herein we report a second-generation, reconfigurable and 25 % smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand-alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards.

AB - As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time-scale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technology, herein we report a second-generation, reconfigurable and 25 % smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand-alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards.

KW - active pharmaceutical ingredients

KW - continuous flow chemistry

KW - industrial chemistry

KW - synthetic methods

UR - https://www.scopus.com/pages/publications/85041183424

U2 - 10.1002/chem.201706004

DO - 10.1002/chem.201706004

M3 - Article

C2 - 29385292

AN - SCOPUS:85041183424

SN - 0947-6539

VL - 24

SP - 2776

EP - 2784

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 11

ER -

Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing

Abstract

UN SDGs

Keywords

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