TY - JOUR
T1 - Advancements in hydrogel design for articular cartilage regeneration
T2 - A comprehensive review
AU - Hashemi-Afzal, Fariba
AU - Fallahi, Hooman
AU - Bagheri, Fatemeh
AU - Collins, Maurice N.
AU - Eslaminejad, Mohamadreza Baghaban
AU - Seitz, Hermann
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2025/1
Y1 - 2025/1
N2 - This review paper explores the cutting-edge advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence worldwide that can lead to joint breakdown at a later stage of the disease, necessitating immediate intervention to prevent progressive degeneration of cartilage. Decades of research into the biomedical applications of hydrogels have revealed their tremendous potential, particularly in soft tissue engineering, including CR. Hydrogels are highly tunable and can be designed to meet the key criteria needed for a template in CR. This paper aims to identify those criteria, including the hydrogel components, mechanical properties, biodegradability, structural design, and integration capability with the adjacent native tissue and delves into the benefits that CR can obtain through appropriate design. Stratified-structural hydrogels that emulate the native cartilage structure, as well as the impact of environmental stimuli on the regeneration outcome, have also been discussed. By examining recent advances and emerging techniques, this paper offers valuable insights into developing effective hydrogel-based therapies for AC repair.
AB - This review paper explores the cutting-edge advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence worldwide that can lead to joint breakdown at a later stage of the disease, necessitating immediate intervention to prevent progressive degeneration of cartilage. Decades of research into the biomedical applications of hydrogels have revealed their tremendous potential, particularly in soft tissue engineering, including CR. Hydrogels are highly tunable and can be designed to meet the key criteria needed for a template in CR. This paper aims to identify those criteria, including the hydrogel components, mechanical properties, biodegradability, structural design, and integration capability with the adjacent native tissue and delves into the benefits that CR can obtain through appropriate design. Stratified-structural hydrogels that emulate the native cartilage structure, as well as the impact of environmental stimuli on the regeneration outcome, have also been discussed. By examining recent advances and emerging techniques, this paper offers valuable insights into developing effective hydrogel-based therapies for AC repair.
KW - Articular cartilage
KW - Environmental stimuli
KW - Hydrogel design
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85203655814&partnerID=8YFLogxK
U2 - 10.1016/j.bioactmat.2024.09.005
DO - 10.1016/j.bioactmat.2024.09.005
M3 - Review article
AN - SCOPUS:85203655814
SN - 2452-199X
VL - 43
SP - 1
EP - 31
JO - Bioactive Materials
JF - Bioactive Materials
ER -