Advances in precision medicine: Tailoring individualized therapies

Kyle B. Matchett; Niamh Lynam-Lennon; R. William Watson; James A.L. Brown

doi:10.3390/cancers9110146

Advances in precision medicine: Tailoring individualized therapies

Kyle B. Matchett, Niamh Lynam-Lennon, R. William Watson, James A.L. Brown

Department of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately stratifying patients and informing cohort-based treatment options. Precision medicine (molecular profiling of individual tumors combined with established clinical-pathological parameters) reveals, in real-time, individual patient's diagnostic and prognostic risk profile, informing tailored and tumor-specific treatment plans. Here we discuss advances in precision medicine presented at the Irish Association for Cancer Research Annual Meeting, highlighting examples where personalized medicine approaches have led to precision discovery in individual tumors, informing customized treatment programs.

Original language	English
Article number	146
Pages (from-to)	-
Journal	Cancers
Volume	9
Issue number	11
DOIs	https://doi.org/10.3390/cancers9110146
Publication status	Published - Nov 2017

Keywords

Avatar
Ireland Cancer Meeting
PDX
Personalized
Precision medicine
Profiling
Xenografts

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers9110146

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title = "Advances in precision medicine: Tailoring individualized therapies",

abstract = "The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately stratifying patients and informing cohort-based treatment options. Precision medicine (molecular profiling of individual tumors combined with established clinical-pathological parameters) reveals, in real-time, individual patient's diagnostic and prognostic risk profile, informing tailored and tumor-specific treatment plans. Here we discuss advances in precision medicine presented at the Irish Association for Cancer Research Annual Meeting, highlighting examples where personalized medicine approaches have led to precision discovery in individual tumors, informing customized treatment programs.",

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KW - Xenografts

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Advances in precision medicine: Tailoring individualized therapies

Abstract

Keywords

UN SDGs

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