Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis

Arja Suzanne Vink; Sally Ann B. Clur; Pieter G. Postema; Nico A. Blom; Arthur A.M. Wilde

doi:10.1007/978-3-030-22672-5_6

Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis

Arja Suzanne Vink, Sally Ann B. Clur, Pieter G. Postema, Nico A. Blom, Arthur A.M. Wilde

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Age, sex and race have an influence on the cardiac repolarization and therefore the QTc-interval. Racial differences are probably the result of the presence of considerable heterogeneity among race/ethnicity for multiple genetic loci that influence the QT-interval. Age-and sex-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of the effect of sex hormones on the QTc-interval and arrhythmogenesis are not known, testosterone appears to shorten the QTc-interval in males. In females, however, there is a more complex interaction between progesterone and oestrogen. In addition, the autonomic nervous system and gonadotropins may play an important part in this complex interaction.

Original language	English
Title of host publication	Cardiac Repolarization
Subtitle of host publication	Basic Science and Clinical Management
Publisher	Springer International Publishing
Pages	119-129
Number of pages	11
ISBN (Electronic)	9783030226725
ISBN (Print)	9783030226718
DOIs	https://doi.org/10.1007/978-3-030-22672-5_6
Publication status	Published - 1 Jan 2019
Externally published	Yes

Keywords

Age
Arrhythmogenesis
Cardiac repolarization
Qt-interval
Racial differences
Sex

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10.1007/978-3-030-22672-5_6

Cite this

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abstract = "Age, sex and race have an influence on the cardiac repolarization and therefore the QTc-interval. Racial differences are probably the result of the presence of considerable heterogeneity among race/ethnicity for multiple genetic loci that influence the QT-interval. Age-and sex-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of the effect of sex hormones on the QTc-interval and arrhythmogenesis are not known, testosterone appears to shorten the QTc-interval in males. In females, however, there is a more complex interaction between progesterone and oestrogen. In addition, the autonomic nervous system and gonadotropins may play an important part in this complex interaction.",

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AU - Clur, Sally Ann B.

AU - Postema, Pieter G.

AU - Blom, Nico A.

AU - Wilde, Arthur A.M.

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N2 - Age, sex and race have an influence on the cardiac repolarization and therefore the QTc-interval. Racial differences are probably the result of the presence of considerable heterogeneity among race/ethnicity for multiple genetic loci that influence the QT-interval. Age-and sex-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of the effect of sex hormones on the QTc-interval and arrhythmogenesis are not known, testosterone appears to shorten the QTc-interval in males. In females, however, there is a more complex interaction between progesterone and oestrogen. In addition, the autonomic nervous system and gonadotropins may play an important part in this complex interaction.

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Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis

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Keywords

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