TY - JOUR
T1 - Alcohol use in adolescence, impulsivity, and risk-taking behavior in Wistar rats
AU - Passos, Jonatas Argemi Foster
AU - Pires, Augusto Viana
AU - Scheidt, Letícia
AU - de Almeida, Luis Alexandre
AU - Ferreira, Charles Francisco
AU - Gubert, Carolina
AU - Bizarro, Lisiane
AU - de Almeida, Rosa Maria Martins
N1 - Publisher Copyright:
© 2015 American Psychological Association.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Adolescence is an important neurodevelopmental stage for brain sites that are related to the impulse control and reward systems. Alcohol abuse during this period may cause irreversible modifications of neural circuits that are linked to impulsivity. The present study evaluated the effects of alcohol ingestion during adolescence in Wistar rats on anxiety, risk-taking, and impulsive behavior parameters during adulthood. Male Wistar rats (n = 40) were randomly assigned to 1 of 3 treatments: 0, 1, and 3 g/kg alcohol administered orally over 9 sessions, from postnatal Day 31 to 50. Anxiety and risk-taking behaviors were assessed in the elevated plus maze soon after adolescence and during adulthood, and impulsivity was assessed in the operant delay-discounting task in adulthood. None of the alcohol treatments altered risk-taking or impulsive behavior compared with the control group. The group that received 3 g/kg alcohol exhibited less anxiety-like behavior in the first exposure to the elevated plus maze compared with the control group. The results are discussed with regard to the doseresponse, frequency, duration, and age of exposure and route of administration.
AB - Adolescence is an important neurodevelopmental stage for brain sites that are related to the impulse control and reward systems. Alcohol abuse during this period may cause irreversible modifications of neural circuits that are linked to impulsivity. The present study evaluated the effects of alcohol ingestion during adolescence in Wistar rats on anxiety, risk-taking, and impulsive behavior parameters during adulthood. Male Wistar rats (n = 40) were randomly assigned to 1 of 3 treatments: 0, 1, and 3 g/kg alcohol administered orally over 9 sessions, from postnatal Day 31 to 50. Anxiety and risk-taking behaviors were assessed in the elevated plus maze soon after adolescence and during adulthood, and impulsivity was assessed in the operant delay-discounting task in adulthood. None of the alcohol treatments altered risk-taking or impulsive behavior compared with the control group. The group that received 3 g/kg alcohol exhibited less anxiety-like behavior in the first exposure to the elevated plus maze compared with the control group. The results are discussed with regard to the doseresponse, frequency, duration, and age of exposure and route of administration.
KW - Adolescence
KW - Anxiety
KW - Delay discounting
KW - Impulsivity
KW - Risk-taking behavior
UR - http://www.scopus.com/inward/record.url?scp=84968624547&partnerID=8YFLogxK
U2 - 10.1037/h0101023
DO - 10.1037/h0101023
M3 - Article
AN - SCOPUS:84968624547
SN - 1984-3054
VL - 8
SP - 130
EP - 142
JO - Psychology and Neuroscience
JF - Psychology and Neuroscience
IS - 1
ER -
