TY - JOUR
T1 - Aminopropyl-functionalized mesoporous silica SBA-15 as drug carrier for cefazolin
T2 - adsorption profiles, release studies, and mineralization potential
AU - Szewczyk, Adrian
AU - Prokopowicz, Magdalena
AU - Sawicki, Wiesław
AU - Majda, Dorota
AU - Walker, Gavin
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/1/15
Y1 - 2019/1/15
N2 - In this study, the effect of 3-aminopropyl surface functionalization of ordered mesoporous silica SBA-15 on cefazolin adsorption and release profiles was investigated. The mineralization potential of functionalized SBA-15 in simulated body fluid was also investigated. The 3-aminopropyl-functionalized SBA-15 (SBA-NH2) were obtained by post-synthesis treatment of the parent SBA-15. The loading of cefazolin on SBA-NH2 was performed by using adsorption process from water solutions. The adsorption efficiency was characterized by applying the Langmuir, Freundlich, and Dubinin–Radushkevich isotherm models. The adsorption kinetics were investigated using pseudo-first and pseudo-second order models as well as intraparticle diffusion model. It was found that the equilibrium data were best fitted by the Langmuir isotherm. Cefazolin adsorption followed the pseudo-second order kinetics. The cefazolin-loaded SBA-NH2 showed prolonged release profile for a period of 7 days. Cefazolin release was characterized by zero-order kinetics with reduced burst release. After 60 days of the mineralization studies the hydroxyapatite was formed on the cefazolin-loaded SBA-NH2 surface. This preliminary study supports the potential use of SBA-NH2 as a bifunctional drug carrier with prolonged cefazolin release and mineralization properties.
AB - In this study, the effect of 3-aminopropyl surface functionalization of ordered mesoporous silica SBA-15 on cefazolin adsorption and release profiles was investigated. The mineralization potential of functionalized SBA-15 in simulated body fluid was also investigated. The 3-aminopropyl-functionalized SBA-15 (SBA-NH2) were obtained by post-synthesis treatment of the parent SBA-15. The loading of cefazolin on SBA-NH2 was performed by using adsorption process from water solutions. The adsorption efficiency was characterized by applying the Langmuir, Freundlich, and Dubinin–Radushkevich isotherm models. The adsorption kinetics were investigated using pseudo-first and pseudo-second order models as well as intraparticle diffusion model. It was found that the equilibrium data were best fitted by the Langmuir isotherm. Cefazolin adsorption followed the pseudo-second order kinetics. The cefazolin-loaded SBA-NH2 showed prolonged release profile for a period of 7 days. Cefazolin release was characterized by zero-order kinetics with reduced burst release. After 60 days of the mineralization studies the hydroxyapatite was formed on the cefazolin-loaded SBA-NH2 surface. This preliminary study supports the potential use of SBA-NH2 as a bifunctional drug carrier with prolonged cefazolin release and mineralization properties.
KW - Adsorption studies
KW - Drug release profiles
KW - Drug-loaded mesoporous silica
KW - Silica's mineralization potential
KW - Surface functionalization
UR - http://www.scopus.com/inward/record.url?scp=85050740969&partnerID=8YFLogxK
U2 - 10.1016/j.micromeso.2018.07.046
DO - 10.1016/j.micromeso.2018.07.046
M3 - Article
AN - SCOPUS:85050740969
SN - 1387-1811
VL - 274
SP - 113
EP - 126
JO - Microporous and Mesoporous Materials
JF - Microporous and Mesoporous Materials
ER -