TY - JOUR
T1 - Amniocentesis prior to physical exam-indicated cerclage in women with midtrimester cervical dilation
T2 - Results from the expectant management compared to physical exam-indicated cerclage international cohort study
AU - Airoldi, James
AU - Pereira, Leonardo
AU - Cotter, Amanda
AU - Gomez, Ricardo
AU - Berghella, Vincenzo
AU - Prasertcharoensuk, Witoon
AU - Rasanen, Juha
AU - Chaithongwongwatthana, Surasith
AU - Mittal, Suneeta
AU - Kearney, Etaion
AU - Tolosa, Jorge E.
PY - 2009/1
Y1 - 2009/1
N2 - We evaluated whether the performance of an amniocentesis in women with a dilated cervix presenting at less than 26 weeks and subsequently managed by a physical exam-indicated cerclage increases the risk of spontaneous preterm birth (PTB) less than 28 weeks. Women between 150/7 to 256/7 weeks' gestation with a dilated cervix (1 to 4 cm) were identified. Multiple exclusion criteria were designated. The primary outcome was PTB less than 28 weeks. One hundred twenty-two women with a dilated cervix between 15 and 256/7 weeks gestational age were identified. Twenty-four (20%) of these had an amniocentesis performed. The unadjusted rate of PTB < 28 weeks differed between women who underwent amniocentesis compared with those who did not (58% versus 34%, respectively, p = 0.02), but after multivariate regression analysis, the performance of an amniocentesis was not an independent contributor to PTB < 28 weeks (p = 0.90). The performance of an amniocentesis prior to cerclage did not independently contribute to PTB less than 28 weeks.
AB - We evaluated whether the performance of an amniocentesis in women with a dilated cervix presenting at less than 26 weeks and subsequently managed by a physical exam-indicated cerclage increases the risk of spontaneous preterm birth (PTB) less than 28 weeks. Women between 150/7 to 256/7 weeks' gestation with a dilated cervix (1 to 4 cm) were identified. Multiple exclusion criteria were designated. The primary outcome was PTB less than 28 weeks. One hundred twenty-two women with a dilated cervix between 15 and 256/7 weeks gestational age were identified. Twenty-four (20%) of these had an amniocentesis performed. The unadjusted rate of PTB < 28 weeks differed between women who underwent amniocentesis compared with those who did not (58% versus 34%, respectively, p = 0.02), but after multivariate regression analysis, the performance of an amniocentesis was not an independent contributor to PTB < 28 weeks (p = 0.90). The performance of an amniocentesis prior to cerclage did not independently contribute to PTB less than 28 weeks.
KW - Amniocentesis
KW - Cerclage
KW - Intra-amniotic infection
KW - Preterm birth
UR - http://www.scopus.com/inward/record.url?scp=58349117270&partnerID=8YFLogxK
U2 - 10.1055/s-0028-1095182
DO - 10.1055/s-0028-1095182
M3 - Article
C2 - 18979415
AN - SCOPUS:58349117270
SN - 0735-1631
VL - 26
SP - 63
EP - 68
JO - American Journal of Perinatology
JF - American Journal of Perinatology
IS - 1
ER -