An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma

Paul G. Murray; Lawrence S. Young

doi:10.1182/blood.2019000568

An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma

Paul G. Murray, Lawrence S. Young

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Although a pathogenic role for the Epstein-Barr virus (EBV) is largely undisputed for tumors that are consistently EBV genome positive (eg, nasopharyngeal carcinoma, endemic Burkitt lymphoma), this is not the case for classical Hodgkin lymphoma (cHL), a tumor with only a variable EBV association. In light of recent developments in immunotherapeutics and small molecules targeting EBV, we believe it is now timely to reevaluate the role of EBV in cHL pathogenesis.

Original language	English
Pages (from-to)	591-596
Number of pages	6
Journal	Blood
Volume	134
Issue number	7
DOIs	https://doi.org/10.1182/blood.2019000568
Publication status	Published - 15 Aug 2019

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abstract = "Although a pathogenic role for the Epstein-Barr virus (EBV) is largely undisputed for tumors that are consistently EBV genome positive (eg, nasopharyngeal carcinoma, endemic Burkitt lymphoma), this is not the case for classical Hodgkin lymphoma (cHL), a tumor with only a variable EBV association. In light of recent developments in immunotherapeutics and small molecules targeting EBV, we believe it is now timely to reevaluate the role of EBV in cHL pathogenesis.",

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AB - Although a pathogenic role for the Epstein-Barr virus (EBV) is largely undisputed for tumors that are consistently EBV genome positive (eg, nasopharyngeal carcinoma, endemic Burkitt lymphoma), this is not the case for classical Hodgkin lymphoma (cHL), a tumor with only a variable EBV association. In light of recent developments in immunotherapeutics and small molecules targeting EBV, we believe it is now timely to reevaluate the role of EBV in cHL pathogenesis.

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An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma

Abstract

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