TY - JOUR
T1 - Anterior cortical development during adolescence in bipolar disorder
AU - Najt, Pablo
AU - Wang, Fei
AU - Spencer, Linda
AU - Johnston, Jennifer A.Y.
AU - Cox Lippard, Elizabeth T.
AU - Pittman, Brian P.
AU - Lacadie, Cheryl
AU - Staib, Lawrence H.
AU - Papademetris, Xenophon
AU - Blumberg, Hilary P.
N1 - Publisher Copyright:
© 2016 Society of Biological Psychiatry.
PY - 2016/2/15
Y1 - 2016/2/15
N2 - Background Increasing evidence supports a neurodevelopmental model for bipolar disorder (BD), with adolescence as a critical period in its development. Developmental abnormalities of anterior paralimbic and heteromodal frontal cortices, key structures in emotional regulation processes and central in BD, are implicated. However, few longitudinal studies have been conducted, limiting understanding of trajectory alterations in BD. In this study, we performed longitudinal neuroimaging of adolescents with and without BD and assessed volume changes over time, including changes in tissue overall and within gray and white matter. Larger decreases over time in anterior cortical volumes in the adolescents with BD were hypothesized. Gray matter decreases and white matter increases are typically observed during adolescence in anterior cortices. It was hypothesized that volume decreases over time in BD would reflect alterations in those processes, showing larger gray matter contraction and decreased white matter expansion. Methods Two high-resolution magnetic resonance imaging scans were obtained approximately 2 years apart for 35 adolescents with bipolar I disorder (BDI) and 37 healthy adolescents. Differences over time between groups were investigated for volume overall and specifically for gray and white matter. Results Relative to healthy adolescents, adolescents with BDI showed greater volume contraction over time in a region including insula and orbitofrontal, rostral, and dorsolateral prefrontal cortices (p <.05, corrected), including greater gray matter contraction and decreased white matter expansion over time, in the BD compared with the healthy group. Conclusions The findings support neurodevelopmental abnormalities during adolescence in BDI in anterior cortices, including altered developmental trajectories of anterior gray and white matter.
AB - Background Increasing evidence supports a neurodevelopmental model for bipolar disorder (BD), with adolescence as a critical period in its development. Developmental abnormalities of anterior paralimbic and heteromodal frontal cortices, key structures in emotional regulation processes and central in BD, are implicated. However, few longitudinal studies have been conducted, limiting understanding of trajectory alterations in BD. In this study, we performed longitudinal neuroimaging of adolescents with and without BD and assessed volume changes over time, including changes in tissue overall and within gray and white matter. Larger decreases over time in anterior cortical volumes in the adolescents with BD were hypothesized. Gray matter decreases and white matter increases are typically observed during adolescence in anterior cortices. It was hypothesized that volume decreases over time in BD would reflect alterations in those processes, showing larger gray matter contraction and decreased white matter expansion. Methods Two high-resolution magnetic resonance imaging scans were obtained approximately 2 years apart for 35 adolescents with bipolar I disorder (BDI) and 37 healthy adolescents. Differences over time between groups were investigated for volume overall and specifically for gray and white matter. Results Relative to healthy adolescents, adolescents with BDI showed greater volume contraction over time in a region including insula and orbitofrontal, rostral, and dorsolateral prefrontal cortices (p <.05, corrected), including greater gray matter contraction and decreased white matter expansion over time, in the BD compared with the healthy group. Conclusions The findings support neurodevelopmental abnormalities during adolescence in BDI in anterior cortices, including altered developmental trajectories of anterior gray and white matter.
KW - Adolescent
KW - Bipolar disorder
KW - Development
KW - Longitudinal studies
KW - Magnetic resonance imaging
KW - Prefrontal cortex
UR - http://www.scopus.com/inward/record.url?scp=84955214154&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2015.03.026
DO - 10.1016/j.biopsych.2015.03.026
M3 - Article
C2 - 26033826
AN - SCOPUS:84955214154
SN - 0006-3223
VL - 79
SP - 303
EP - 310
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 4
ER -