Antihypertensive effects of Artemisia scoparia waldst in spontaneously hypertensive rats and identification of angiotensin I converting enzyme inhibitors

Jeong Yong Cho; Kyung Hee Park; Do Young Hwang; Saoraya Chanmuang; Lily Jaiswal; Yang Kyun Park; Sun Young Park; So Young Kim; Haeng Ran Kim; Jae Hak Moon; Kyung Sik Ham

doi:10.3390/molecules201119657

Antihypertensive effects of Artemisia scoparia waldst in spontaneously hypertensive rats and identification of angiotensin I converting enzyme inhibitors

Jeong Yong Cho
, Kyung Hee Park
, Do Young Hwang
, Saoraya Chanmuang
, Lily Jaiswal
, Yang Kyun Park
, Sun Young Park
, So Young Kim
, Haeng Ran Kim
, Jae Hak Moon
, Kyung Sik Ham

Department of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the antihypertensive effects of Artemisia scoparia (AS) in spontaneously hypertensive rats (SHR). The rats were fed diets containing 2% (w/w) hot water extracts of AS aerial parts for 6 weeks. The AS group had significantly lower systolic and diastolic blood pressure levels than the control group. The AS group also had lower angiotensin I converting enzyme (ACE) activity and angiotensin II content in serum compared to the control group. The AS group showed higher vascular endothelial growth factor and lower ras homolog gene family member A expression levels in kidney compared to the control group. The AS group had significantly lower levels of plasma lipid oxidation and protein carbonyls than the control group. One new and six known compounds were isolated from AS by guided purification. The new compound was determined to be 4′-O-β-D-glucopyranoyl (E)-4-hydroxy-3-methylbut-2-enyl benzoate, based on its nuclear magnetic resonance and electrospray ionization-mass spectroscopy data.

Original language	English (Ireland)
Pages (from-to)	19789-19804
Number of pages	16
Journal	Molecules
Volume	20
Issue number	11
DOIs	https://doi.org/10.3390/molecules201119657
Publication status	Published - 3 Nov 2015

Keywords

ACE inhibitor
Artemisia scoparia
Blood pressure
Halophyte
Phenolics

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10.3390/molecules201119657

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Cho, J. Y., Park, K. H., Hwang, D. Y., Chanmuang, S., Jaiswal, L., Park, Y. K., Park, S. Y., Kim, S. Y., Kim, H. R., Moon, J. H., & Ham, K. S. (2015). Antihypertensive effects of Artemisia scoparia waldst in spontaneously hypertensive rats and identification of angiotensin I converting enzyme inhibitors. Molecules, 20(11), 19789-19804. https://doi.org/10.3390/molecules201119657

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title = "Antihypertensive effects of Artemisia scoparia waldst in spontaneously hypertensive rats and identification of angiotensin I converting enzyme inhibitors",

abstract = "We investigated the antihypertensive effects of Artemisia scoparia (AS) in spontaneously hypertensive rats (SHR). The rats were fed diets containing 2\% (w/w) hot water extracts of AS aerial parts for 6 weeks. The AS group had significantly lower systolic and diastolic blood pressure levels than the control group. The AS group also had lower angiotensin I converting enzyme (ACE) activity and angiotensin II content in serum compared to the control group. The AS group showed higher vascular endothelial growth factor and lower ras homolog gene family member A expression levels in kidney compared to the control group. The AS group had significantly lower levels of plasma lipid oxidation and protein carbonyls than the control group. One new and six known compounds were isolated from AS by guided purification. The new compound was determined to be 4′-O-β-D-glucopyranoyl (E)-4-hydroxy-3-methylbut-2-enyl benzoate, based on its nuclear magnetic resonance and electrospray ionization-mass spectroscopy data.",

keywords = "ACE inhibitor, Artemisia scoparia, Blood pressure, Halophyte, Phenolics",

author = "Cho, \{Jeong Yong\} and Park, \{Kyung Hee\} and Hwang, \{Do Young\} and Saoraya Chanmuang and Lily Jaiswal and Park, \{Yang Kyun\} and Park, \{Sun Young\} and Kim, \{So Young\} and Kim, \{Haeng Ran\} and Moon, \{Jae Hak\} and Ham, \{Kyung Sik\}",

note = "Publisher Copyright: {\textcopyright} 2015 by The Authors.",

year = "2015",

month = nov,

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doi = "10.3390/molecules201119657",

language = "English (Ireland)",

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AU - Cho, Jeong Yong

AU - Park, Kyung Hee

AU - Hwang, Do Young

AU - Chanmuang, Saoraya

AU - Jaiswal, Lily

AU - Park, Yang Kyun

AU - Park, Sun Young

AU - Kim, So Young

AU - Kim, Haeng Ran

AU - Moon, Jae Hak

AU - Ham, Kyung Sik

PY - 2015/11/3

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N2 - We investigated the antihypertensive effects of Artemisia scoparia (AS) in spontaneously hypertensive rats (SHR). The rats were fed diets containing 2% (w/w) hot water extracts of AS aerial parts for 6 weeks. The AS group had significantly lower systolic and diastolic blood pressure levels than the control group. The AS group also had lower angiotensin I converting enzyme (ACE) activity and angiotensin II content in serum compared to the control group. The AS group showed higher vascular endothelial growth factor and lower ras homolog gene family member A expression levels in kidney compared to the control group. The AS group had significantly lower levels of plasma lipid oxidation and protein carbonyls than the control group. One new and six known compounds were isolated from AS by guided purification. The new compound was determined to be 4′-O-β-D-glucopyranoyl (E)-4-hydroxy-3-methylbut-2-enyl benzoate, based on its nuclear magnetic resonance and electrospray ionization-mass spectroscopy data.

AB - We investigated the antihypertensive effects of Artemisia scoparia (AS) in spontaneously hypertensive rats (SHR). The rats were fed diets containing 2% (w/w) hot water extracts of AS aerial parts for 6 weeks. The AS group had significantly lower systolic and diastolic blood pressure levels than the control group. The AS group also had lower angiotensin I converting enzyme (ACE) activity and angiotensin II content in serum compared to the control group. The AS group showed higher vascular endothelial growth factor and lower ras homolog gene family member A expression levels in kidney compared to the control group. The AS group had significantly lower levels of plasma lipid oxidation and protein carbonyls than the control group. One new and six known compounds were isolated from AS by guided purification. The new compound was determined to be 4′-O-β-D-glucopyranoyl (E)-4-hydroxy-3-methylbut-2-enyl benzoate, based on its nuclear magnetic resonance and electrospray ionization-mass spectroscopy data.

KW - ACE inhibitor

KW - Artemisia scoparia

KW - Blood pressure

KW - Halophyte

KW - Phenolics

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M3 - Article

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SN - 1420-3049

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JO - Molecules

JF - Molecules

IS - 11

ER -

Antihypertensive effects of Artemisia scoparia waldst in spontaneously hypertensive rats and identification of angiotensin I converting enzyme inhibitors

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Keywords

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