Antioxidant/pro-oxidant and antiproliferative activities of phenolic-rich foods and extracts: A cell-based point of view

Mariana Araújo Vieira do Carmo, Daniel Granato, Luciana Azevedo

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Phenolic compounds have demonstrated several in vitro beneficial properties by acting as antioxidant and pro-oxidant agents. This chapter approaches the relationship among oxidative stress, cancer, phenolic compounds and antiproliferative activity. Moreover, it discusses in vitro techniques and their biological applications, regarding cell viability and intracellular measure of reactive oxygen assays. The in vitro methods are important tools for screening and understanding the pathways involved on antiproliferative and antioxidant/pro-oxidant effects of phenolic compounds. These findings open avenues for the development of innovative food, chemical structures, technological applications and future perspectives in this research field.

Original languageEnglish
Title of host publicationApplication of Polyphenols in Foods and Food Models
EditorsDaniel Granato
PublisherAcademic Press Inc.
Pages253-280
Number of pages28
ISBN (Print)9780128225066
DOIs
Publication statusPublished - Jan 2021

Publication series

NameAdvances in Food and Nutrition Research
Volume98
ISSN (Print)1043-4526

Keywords

  • Cancer
  • Cell culture
  • Cell viability
  • In vitro methods
  • Oxidative stress
  • Phenolic compounds
  • Reactive oxygen species

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