TY - JOUR
T1 - Antioxidative potential of antidiabetic agents
T2 - A possible protective mechanism against vascular complications in diabetic patients
AU - Yaribeygi, Habib
AU - Butler, Alexandra E.
AU - Barreto, George E.
AU - Sahebkar, Amirhossein
N1 - Publisher Copyright:
© 2018 Wiley Periodicals, Inc.
PY - 2019/3
Y1 - 2019/3
N2 - Many vascular complications are related to exposure of tissues to elevated levels of glucose, a condition that promotes oxidative stress. The primary goal of antidiabetic medication is for normalization of blood glucose. However, antidiabetic medications may have antioxidant effects that go beyond their hypoglycemic influences. Therefore, antidiabetic drugs may be doubly beneficial in preventing diabetic complications. Vascular dysfunction due to uncontrolled diabetes is a serious complication of the disease and one which has a severe impact on quality of life. Readjustment of the oxidative balance in subjects with diabetes, and the positive effects thereof is a topic of intense interest at present. In the current review, we highlight the antioxidant effects of antidiabetic medications which may prevent or delay the onset of vascular dysfunction.
AB - Many vascular complications are related to exposure of tissues to elevated levels of glucose, a condition that promotes oxidative stress. The primary goal of antidiabetic medication is for normalization of blood glucose. However, antidiabetic medications may have antioxidant effects that go beyond their hypoglycemic influences. Therefore, antidiabetic drugs may be doubly beneficial in preventing diabetic complications. Vascular dysfunction due to uncontrolled diabetes is a serious complication of the disease and one which has a severe impact on quality of life. Readjustment of the oxidative balance in subjects with diabetes, and the positive effects thereof is a topic of intense interest at present. In the current review, we highlight the antioxidant effects of antidiabetic medications which may prevent or delay the onset of vascular dysfunction.
KW - antidiabetic medications
KW - diabetes
KW - diabetic nephropathy (DN)
KW - oxidative stress
KW - vascular dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85052943119&partnerID=8YFLogxK
U2 - 10.1002/jcp.27278
DO - 10.1002/jcp.27278
M3 - Review article
C2 - 30191997
AN - SCOPUS:85052943119
SN - 0021-9541
VL - 234
SP - 2436
EP - 2446
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
IS - 3
ER -