Antioxidative potential of antidiabetic agents: A possible protective mechanism against vascular complications in diabetic patients

Habib Yaribeygi, Alexandra E. Butler, George E. Barreto, Amirhossein Sahebkar

Research output: Contribution to journalReview articlepeer-review

Abstract

Many vascular complications are related to exposure of tissues to elevated levels of glucose, a condition that promotes oxidative stress. The primary goal of antidiabetic medication is for normalization of blood glucose. However, antidiabetic medications may have antioxidant effects that go beyond their hypoglycemic influences. Therefore, antidiabetic drugs may be doubly beneficial in preventing diabetic complications. Vascular dysfunction due to uncontrolled diabetes is a serious complication of the disease and one which has a severe impact on quality of life. Readjustment of the oxidative balance in subjects with diabetes, and the positive effects thereof is a topic of intense interest at present. In the current review, we highlight the antioxidant effects of antidiabetic medications which may prevent or delay the onset of vascular dysfunction.

Original languageEnglish
Pages (from-to)2436-2446
Number of pages11
JournalJournal of Cellular Physiology
Volume234
Issue number3
DOIs
Publication statusPublished - Mar 2019

Keywords

  • antidiabetic medications
  • diabetes
  • diabetic nephropathy (DN)
  • oxidative stress
  • vascular dysfunction

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