Application of QbD Framework for Development of Self-Emulsifying Drug Delivery Systems

Sabya Sachi Das; Avi Singh; Sweta Kar; Riya Ghosh; Moumita Pal; Meher Fatima; Neeru Singh; Sandeep Kumar Singh

doi:10.1016/B978-0-12-815799-2.00015-0

Application of QbD Framework for Development of Self-Emulsifying Drug Delivery Systems

Sabya Sachi Das
, Avi Singh
, Sweta Kar
, Riya Ghosh
, Moumita Pal
, Meher Fatima
, Neeru Singh
, Sandeep Kumar Singh

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The chapter largely focuses on the application quality by design (QbD) on self-emulsifying drug delivery system (SEDDS). SEDDS, an isotropic mixture of lipid, surfactant, cosurfactant, and drug, is a promising technology to improve the bioavailability of poorly water-soluble drugs. The chapter is primarily sectioned into (a) application of Box-Behnken design in SEDDS, (b) application of central-composite design in SEDDS, (c) application of D-optimal design in SEDDS (d) application of full-factorial design in SEDD, and (e) application of simplex-lattice design in SEDDS, followed by an exhaustive table illustrating the application of QbD in SEDDS. The literature reviews on QbD on SEDDS unequivocally exemplify the wide acceptance of application of the statistical tool in the development of SEDDS.

Original language	English
Title of host publication	Pharmaceutical Quality by Design
Subtitle of host publication	Principles and Applications
Publisher	Elsevier
Pages	297-350
Number of pages	54
ISBN (Electronic)	9780128157992
DOIs	https://doi.org/10.1016/B978-0-12-815799-2.00015-0
Publication status	Published - 1 Jan 2019
Externally published	Yes

Keywords

Box-Behnken design
Central composite design
D-optimal design
Factorial design
Quality by design
Self-emulsifying drug delivery system

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10.1016/B978-0-12-815799-2.00015-0

Cite this

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title = "Application of QbD Framework for Development of Self-Emulsifying Drug Delivery Systems",

abstract = "The chapter largely focuses on the application quality by design (QbD) on self-emulsifying drug delivery system (SEDDS). SEDDS, an isotropic mixture of lipid, surfactant, cosurfactant, and drug, is a promising technology to improve the bioavailability of poorly water-soluble drugs. The chapter is primarily sectioned into (a) application of Box-Behnken design in SEDDS, (b) application of central-composite design in SEDDS, (c) application of D-optimal design in SEDDS (d) application of full-factorial design in SEDD, and (e) application of simplex-lattice design in SEDDS, followed by an exhaustive table illustrating the application of QbD in SEDDS. The literature reviews on QbD on SEDDS unequivocally exemplify the wide acceptance of application of the statistical tool in the development of SEDDS.",

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AU - Kar, Sweta

AU - Ghosh, Riya

AU - Pal, Moumita

AU - Fatima, Meher

AU - Singh, Neeru

AU - Singh, Sandeep Kumar

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KW - Central composite design

KW - D-optimal design

KW - Factorial design

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BT - Pharmaceutical Quality by Design

PB - Elsevier

ER -

Application of QbD Framework for Development of Self-Emulsifying Drug Delivery Systems

Abstract

Keywords

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