Assessment of antioxidant activity, lipid profile, general biochemical and immune system responses of Wistar rats fed with dairy dessert containing Lactobacillus acidophilus La-5

C. S. Moura, P. C.B. Lollo, P. N. Morato, E. A. Esmerino, L. P. Margalho, V. A. Santos-Junior, P. T. Coimbra, L. P. Cappato, M. C. Silva, A. S. Garcia-Gomes, D. Granato, H. M.A. Bolini, A. S. Sant'Ana, A. G. Cruz, Jaime Amaya-Farfan

Research output: Contribution to journalArticlepeer-review

Abstract

The viability and survival of Lactobacillus acidophilus La5 under in vitro simulated gastrointestinal in probiotic dairy dessert was assessed. In addition, the effects of regular consumption of the dessert (5 g/day) on the lipid profile, immune system, and antioxidant/biochemical status of Wistar rats were also evaluated after 2 weeks of treatment. Adequate counts of L. acidophilus La-5 were observed regards the viability and gastrointestinal conditions. The probiotic dairy dessert was efficient in reducing the LDL-cholesterol, triacylglycerol and increased the HDL-cholesterol in serum. Aspartate amino transferase, alanine aminotransferase, total protein, albumin, heat shock proteins, immune system responses, and blood-cells counts (monocyte, lymphocyte, neutrophil and leucocyte) were not affected (p > 0.05) after 15 days of treatment. Overall, the probiotic dairy dessert may be a viable alternative to enhance the blood lipid profile and could be used to improve the antioxidant defenses.

Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalFood Research International
Volume90
DOIs
Publication statusPublished - 1 Dec 2016
Externally publishedYes

Keywords

  • Antioxidant defense
  • Dairy dessert
  • Immune system
  • Probiotic bacteria

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