TY - JOUR
T1 - Association of baseline and cumulative remnant cholesterol with incidence of diabetic nephropathy
T2 - A longitudinal cohort study
AU - Wu, Zhiyuan
AU - Yu, Siqi
AU - Zhu, Qian
AU - Li, Zhiwei
AU - Zhang, Haiping
AU - Kang, Xiaoping
AU - Xu, Zongkai
AU - Miao, Xinlei
AU - Liu, Xiangtong
AU - Li, Xia
AU - Zhang, Jingbo
AU - Wang, Wei
AU - Tao, Lixin
AU - Guo, Xiuhua
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/9
Y1 - 2022/9
N2 - Aims: To evaluate the longitudinal association of remnant cholesterol with the incidence of diabetic nephropathy using a Chinese diabetes cohort. Methods: We included 4237 individuals with type 2 diabetes during 2013–2014 from Beijing Health Management Cohort. Remnant cholesterol was defined by Martin–Hopkins equation. Diabetic nephropathy was confirmed by urine albumin/creatinine ratio and estimated glomerular filtration rate. We calculated the hazard ratio (HR) and 95% confidence interval (CI) for incident diabetic nephropathy using adjusted Cox proportional hazards regression. Results: The median [IQR] age was 55 [48, 64] years, and 3 256 (76.8 %) were men. During follow-up, 248 (5.9 %) participants developed diabetic nephropathy. One-SD increase of baseline and average cumulative remnant cholesterol were significantly associated with an increased risk of diabetic nephropathy, and the adjusted HRs were 1.208 (95 % CI: 1.098–1.329) and 1.216 (95 % CI: 1.102–1.341), respectively. Individuals in the highest tertile of baseline and average cumulative remnant cholesterol had a 82.3 % and 87.6 % excess risk of diabetic nephropathy, compared with those in the lowest. Conclusion: Remnant cholesterol is independently associated with incident diabetic nephropathy in type 2 diabetes.
AB - Aims: To evaluate the longitudinal association of remnant cholesterol with the incidence of diabetic nephropathy using a Chinese diabetes cohort. Methods: We included 4237 individuals with type 2 diabetes during 2013–2014 from Beijing Health Management Cohort. Remnant cholesterol was defined by Martin–Hopkins equation. Diabetic nephropathy was confirmed by urine albumin/creatinine ratio and estimated glomerular filtration rate. We calculated the hazard ratio (HR) and 95% confidence interval (CI) for incident diabetic nephropathy using adjusted Cox proportional hazards regression. Results: The median [IQR] age was 55 [48, 64] years, and 3 256 (76.8 %) were men. During follow-up, 248 (5.9 %) participants developed diabetic nephropathy. One-SD increase of baseline and average cumulative remnant cholesterol were significantly associated with an increased risk of diabetic nephropathy, and the adjusted HRs were 1.208 (95 % CI: 1.098–1.329) and 1.216 (95 % CI: 1.102–1.341), respectively. Individuals in the highest tertile of baseline and average cumulative remnant cholesterol had a 82.3 % and 87.6 % excess risk of diabetic nephropathy, compared with those in the lowest. Conclusion: Remnant cholesterol is independently associated with incident diabetic nephropathy in type 2 diabetes.
KW - Cohort study
KW - Diabetic nephropathy
KW - Lipid profile
KW - Remnant cholesterol
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85138112842&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2022.110079
DO - 10.1016/j.diabres.2022.110079
M3 - Article
C2 - 36099974
AN - SCOPUS:85138112842
SN - 0168-8227
VL - 191
SP - 110079
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 110079
ER -