Association of baseline and cumulative remnant cholesterol with incidence of diabetic nephropathy: A longitudinal cohort study

Zhiyuan Wu, Siqi Yu, Qian Zhu, Zhiwei Li, Haiping Zhang, Xiaoping Kang, Zongkai Xu, Xinlei Miao, Xiangtong Liu, Xia Li, Jingbo Zhang, Wei Wang, Lixin Tao, Xiuhua Guo

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To evaluate the longitudinal association of remnant cholesterol with the incidence of diabetic nephropathy using a Chinese diabetes cohort. Methods: We included 4237 individuals with type 2 diabetes during 2013–2014 from Beijing Health Management Cohort. Remnant cholesterol was defined by Martin–Hopkins equation. Diabetic nephropathy was confirmed by urine albumin/creatinine ratio and estimated glomerular filtration rate. We calculated the hazard ratio (HR) and 95% confidence interval (CI) for incident diabetic nephropathy using adjusted Cox proportional hazards regression. Results: The median [IQR] age was 55 [48, 64] years, and 3 256 (76.8 %) were men. During follow-up, 248 (5.9 %) participants developed diabetic nephropathy. One-SD increase of baseline and average cumulative remnant cholesterol were significantly associated with an increased risk of diabetic nephropathy, and the adjusted HRs were 1.208 (95 % CI: 1.098–1.329) and 1.216 (95 % CI: 1.102–1.341), respectively. Individuals in the highest tertile of baseline and average cumulative remnant cholesterol had a 82.3 % and 87.6 % excess risk of diabetic nephropathy, compared with those in the lowest. Conclusion: Remnant cholesterol is independently associated with incident diabetic nephropathy in type 2 diabetes.

Original languageEnglish
Article number110079
Pages (from-to)110079
JournalDiabetes Research and Clinical Practice
Volume191
DOIs
Publication statusPublished - Sep 2022
Externally publishedYes

Keywords

  • Cohort study
  • Diabetic nephropathy
  • Lipid profile
  • Remnant cholesterol
  • Type 2 diabetes

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