Astrocyte proliferation following stroke in the mouse depends on distance from the infarct

George E. Barreto, Xiaoyun Sun, Lijun Xu, Rona G. Giffard

Research output: Contribution to journalArticlepeer-review

Abstract

Reactive gliosis is a hallmark of brain pathology and the injury response, yet the extent to which astrocytes proliferate, and whether this is central to astrogliosis is still controversial. We determined the fraction of mature astrocytes that proliferate in a mouse stroke model using unbiased stereology as a function of distance from the infarct edge. Cumulatively 11.1±1.2% of Aldh1l1 + astrocytes within 400 μm in the cortical penumbra incorporate BrdU in the first week following stroke, while the overall number of astrocytes does not change. The number of astrocytes proliferating fell sharply with distance with more than half of all proliferating astrocytes found within 100 μm of the edge of the infarct. Despite extensive cell proliferation primarily of microglia and neutrophils/monocytes in the week following stroke, few mature astrocytes re-enter cell cycle, and these are concentrated close to the infarct boundary.

Original languageEnglish
Article numbere27881
Pages (from-to)e27881
JournalPLoS ONE
Volume6
Issue number11
DOIs
Publication statusPublished - 21 Nov 2011
Externally publishedYes

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