Bioink: a 3D-bioprinting tool for anticancer drug discovery and cancer management

Arpita P. Tiwari, Nanasaheb D. Thorat, Sabrina Pricl, Rakesh M. Patil, Sonali Rohiwal, Helen Townley

Research output: Contribution to journalReview articlepeer-review

Abstract

‘Bioinks’ are important tools for the fabrication of artificial living-tissue constructs that are able to mimic all properties of native tissues via 3D bioprinting technologies. Bioinks are most commonly made by incorporating live cells of interest within a natural or synthetic biocompatible polymeric matrix. In oncology research, the ability to recreate a tumor microenvironment (TME) using by 3D bioprinting constitutes a promising approach for drug development, screening, and in vitro cancer modeling. Here, we review the different types of bioink used for 3D bioprinting, with a focus on its application in cancer management. In addition, we consider the fabrication of bioink using customized materials/cells and their properties in the field of cancer drug discovery.

Original languageEnglish
Pages (from-to)1574-1590
Number of pages17
JournalDrug Discovery Today
Volume26
Issue number7
DOIs
Publication statusPublished - Jul 2021
Externally publishedYes

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