TY - JOUR
T1 - Bioink
T2 - a 3D-bioprinting tool for anticancer drug discovery and cancer management
AU - Tiwari, Arpita P.
AU - Thorat, Nanasaheb D.
AU - Pricl, Sabrina
AU - Patil, Rakesh M.
AU - Rohiwal, Sonali
AU - Townley, Helen
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/7
Y1 - 2021/7
N2 - ‘Bioinks’ are important tools for the fabrication of artificial living-tissue constructs that are able to mimic all properties of native tissues via 3D bioprinting technologies. Bioinks are most commonly made by incorporating live cells of interest within a natural or synthetic biocompatible polymeric matrix. In oncology research, the ability to recreate a tumor microenvironment (TME) using by 3D bioprinting constitutes a promising approach for drug development, screening, and in vitro cancer modeling. Here, we review the different types of bioink used for 3D bioprinting, with a focus on its application in cancer management. In addition, we consider the fabrication of bioink using customized materials/cells and their properties in the field of cancer drug discovery.
AB - ‘Bioinks’ are important tools for the fabrication of artificial living-tissue constructs that are able to mimic all properties of native tissues via 3D bioprinting technologies. Bioinks are most commonly made by incorporating live cells of interest within a natural or synthetic biocompatible polymeric matrix. In oncology research, the ability to recreate a tumor microenvironment (TME) using by 3D bioprinting constitutes a promising approach for drug development, screening, and in vitro cancer modeling. Here, we review the different types of bioink used for 3D bioprinting, with a focus on its application in cancer management. In addition, we consider the fabrication of bioink using customized materials/cells and their properties in the field of cancer drug discovery.
UR - http://www.scopus.com/inward/record.url?scp=85103536793&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2021.03.010
DO - 10.1016/j.drudis.2021.03.010
M3 - Review article
C2 - 33741496
AN - SCOPUS:85103536793
SN - 1359-6446
VL - 26
SP - 1574
EP - 1590
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 7
ER -