Biological evaluation of nano-hydroxyapatite-zirconia (HA-ZrO2) composites and strontium-hydroxyapatite (Sr-HA) for load-bearing applications

Ian Brook; Christine Freeman; Sarah Grubb; Niamh Cummins; Declan Curran; Colin Reidy; Stuart Hampshire; Mark Towler

doi:10.1177/0885328211403020

Biological evaluation of nano-hydroxyapatite-zirconia (HA-ZrO2) composites and strontium-hydroxyapatite (Sr-HA) for load-bearing applications

Ian Brook
, Christine Freeman
, Sarah Grubb
, Niamh Cummins
, Declan Curran
, Colin Reidy
, Stuart Hampshire
, Mark Towler

University of Sheffield
University of Limerick
Alfred University

Research output: Contribution to journal › Article › peer-review

Abstract

The biological response of strontium (Sr) doped hydroxyapatite (HA) and hydroxyapatite-zirconia (HA-ZrO2) composites produced by employing sol-gel technology, minimal ZrO2 loadings, and novel microwave-sintering regimes thereby retarding decomposition, is reported. In vitro evaluations indicate that all materials induce a favorable response from rat osteosarcoma cells. In vivo evaluations show osteoconductivity and biocompatibility for both the Sr-HA and HA-ZrO2. The materials did not cause any inflammatory response in bone. The Sr-HA displays better biocompatibility which may be due to the incorporation of Sr and the formation of a surface apatite layer.

Original language	English
Pages (from-to)	291-298
Number of pages	8
Journal	Journal of Biomaterials Applications
Volume	27
Issue number	3
DOIs	https://doi.org/10.1177/0885328211403020
Publication status	Published - Sep 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Hydroxyapatite
animal trial
in vitro
in vivo
strontium
zirconia

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10.1177/0885328211403020

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title = "Biological evaluation of nano-hydroxyapatite-zirconia (HA-ZrO2) composites and strontium-hydroxyapatite (Sr-HA) for load-bearing applications",

abstract = "The biological response of strontium (Sr) doped hydroxyapatite (HA) and hydroxyapatite-zirconia (HA-ZrO2) composites produced by employing sol-gel technology, minimal ZrO2 loadings, and novel microwave-sintering regimes thereby retarding decomposition, is reported. In vitro evaluations indicate that all materials induce a favorable response from rat osteosarcoma cells. In vivo evaluations show osteoconductivity and biocompatibility for both the Sr-HA and HA-ZrO2. The materials did not cause any inflammatory response in bone. The Sr-HA displays better biocompatibility which may be due to the incorporation of Sr and the formation of a surface apatite layer.",

keywords = "Hydroxyapatite, animal trial, in vitro, in vivo, strontium, zirconia",

author = "Ian Brook and Christine Freeman and Sarah Grubb and Niamh Cummins and Declan Curran and Colin Reidy and Stuart Hampshire and Mark Towler",

year = "2012",

month = sep,

doi = "10.1177/0885328211403020",

language = "English",

volume = "27",

pages = "291--298",

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T1 - Biological evaluation of nano-hydroxyapatite-zirconia (HA-ZrO2) composites and strontium-hydroxyapatite (Sr-HA) for load-bearing applications

AU - Brook, Ian

AU - Freeman, Christine

AU - Grubb, Sarah

AU - Cummins, Niamh

AU - Curran, Declan

AU - Reidy, Colin

AU - Hampshire, Stuart

AU - Towler, Mark

PY - 2012/9

Y1 - 2012/9

N2 - The biological response of strontium (Sr) doped hydroxyapatite (HA) and hydroxyapatite-zirconia (HA-ZrO2) composites produced by employing sol-gel technology, minimal ZrO2 loadings, and novel microwave-sintering regimes thereby retarding decomposition, is reported. In vitro evaluations indicate that all materials induce a favorable response from rat osteosarcoma cells. In vivo evaluations show osteoconductivity and biocompatibility for both the Sr-HA and HA-ZrO2. The materials did not cause any inflammatory response in bone. The Sr-HA displays better biocompatibility which may be due to the incorporation of Sr and the formation of a surface apatite layer.

AB - The biological response of strontium (Sr) doped hydroxyapatite (HA) and hydroxyapatite-zirconia (HA-ZrO2) composites produced by employing sol-gel technology, minimal ZrO2 loadings, and novel microwave-sintering regimes thereby retarding decomposition, is reported. In vitro evaluations indicate that all materials induce a favorable response from rat osteosarcoma cells. In vivo evaluations show osteoconductivity and biocompatibility for both the Sr-HA and HA-ZrO2. The materials did not cause any inflammatory response in bone. The Sr-HA displays better biocompatibility which may be due to the incorporation of Sr and the formation of a surface apatite layer.

KW - Hydroxyapatite

KW - animal trial

KW - in vitro

KW - in vivo

KW - strontium

KW - zirconia

UR - https://www.scopus.com/pages/publications/84865448073

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DO - 10.1177/0885328211403020

M3 - Article

C2 - 21926146

AN - SCOPUS:84865448073

SN - 0885-3282

VL - 27

SP - 291

EP - 298

JO - Journal of Biomaterials Applications

JF - Journal of Biomaterials Applications

IS - 3

ER -

Biological evaluation of nano-hydroxyapatite-zirconia (HA-ZrO2) composites and strontium-hydroxyapatite (Sr-HA) for load-bearing applications

Abstract

UN SDGs

Keywords

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