Abstract
Aims. The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. Methods and results. This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas. Conclusions. BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.
Original language | English |
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Pages (from-to) | 1-6 |
Number of pages | 6 |
Journal | Biomedical Papers |
Volume | 156 |
Issue number | 1 |
DOIs | |
Publication status | Published - Mar 2012 |
Externally published | Yes |
Keywords
- BLIMP1
- DLBCL
- Epstein-Barr virus
- Review