Cadmium selenide sulfide quantum dots with tuneable emission profiles: An electrochemiluminescence platform for the determination of TIMP-1 protein

Siobhán O'Connor; Luluh Al Hassan; Grace Brennan; Kieran McCarthy; Christophe Silien; Ning Liu; Tadhg Kennedy; Kevin Ryan; Emmet O'Reilly

doi:10.1016/j.bioelechem.2022.108221

Cadmium selenide sulfide quantum dots with tuneable emission profiles: An electrochemiluminescence platform for the determination of TIMP-1 protein

Siobhán O'Connor, Luluh Al Hassan, Grace Brennan, Kieran McCarthy, Christophe Silien, Ning Liu, Tadhg Kennedy, Kevin Ryan, Emmet O'Reilly

University of Limerick

Research output: Contribution to journal › Article › peer-review

Abstract

The development of electrochemiluminescent (ECL) luminophores with tuneable emission profiles is a key requirement in the development of multi-analyte ECL sensing platforms. This study presents the first reported use of cadmium selenide sulfide (CdSeS) quantum dots (QDs) as ECL emitters in which both the ECL emission profile and cathodic potential can be tailored by alteration of the Se/S ratio. CdSeS QDs were synthesised using an aqueous synthetic route thereby avoiding the use of organic reagents, high temperatures and inert gasses. The suitability of the CdSeS QDs to ECL sensing applications is demonstrated via the quantitative determination of TIMP-1 protein at clinically relevant concentrations. The developed cathodic ECL immunosensor exhibited a detectable linear range of 6–60 ng/mL and a limit of detection (LOD) of 1.54 ng/mL. TIMP-1 protein plays a crucial role in pregnancy, wound healing, and cancer prognosis.

Original language	English
Article number	108221
Pages (from-to)	-
Journal	Bioelectrochemistry
Volume	148
DOIs	https://doi.org/10.1016/j.bioelechem.2022.108221
Publication status	Published - Dec 2022

Keywords

CdSeS
Electrochemiluminescence
Nanoparticle
Point of care biosensing
TIMP 1 protein
Tuneable emission

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bioelechem.2022.108221

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title = "Cadmium selenide sulfide quantum dots with tuneable emission profiles: An electrochemiluminescence platform for the determination of TIMP-1 protein",

abstract = "The development of electrochemiluminescent (ECL) luminophores with tuneable emission profiles is a key requirement in the development of multi-analyte ECL sensing platforms. This study presents the first reported use of cadmium selenide sulfide (CdSeS) quantum dots (QDs) as ECL emitters in which both the ECL emission profile and cathodic potential can be tailored by alteration of the Se/S ratio. CdSeS QDs were synthesised using an aqueous synthetic route thereby avoiding the use of organic reagents, high temperatures and inert gasses. The suitability of the CdSeS QDs to ECL sensing applications is demonstrated via the quantitative determination of TIMP-1 protein at clinically relevant concentrations. The developed cathodic ECL immunosensor exhibited a detectable linear range of 6–60 ng/mL and a limit of detection (LOD) of 1.54 ng/mL. TIMP-1 protein plays a crucial role in pregnancy, wound healing, and cancer prognosis.",

keywords = "CdSeS, Electrochemiluminescence, Nanoparticle, Point of care biosensing, TIMP 1 protein, Tuneable emission",

author = "Siobh{\'a}n O'Connor and {Al Hassan}, Luluh and Grace Brennan and Kieran McCarthy and Christophe Silien and Ning Liu and Tadhg Kennedy and Kevin Ryan and Emmet O'Reilly",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

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doi = "10.1016/j.bioelechem.2022.108221",

language = "English",

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T2 - An electrochemiluminescence platform for the determination of TIMP-1 protein

AU - O'Connor, Siobhán

AU - Al Hassan, Luluh

AU - Brennan, Grace

AU - McCarthy, Kieran

AU - Silien, Christophe

AU - Liu, Ning

AU - Kennedy, Tadhg

AU - Ryan, Kevin

AU - O'Reilly, Emmet

PY - 2022/12

Y1 - 2022/12

N2 - The development of electrochemiluminescent (ECL) luminophores with tuneable emission profiles is a key requirement in the development of multi-analyte ECL sensing platforms. This study presents the first reported use of cadmium selenide sulfide (CdSeS) quantum dots (QDs) as ECL emitters in which both the ECL emission profile and cathodic potential can be tailored by alteration of the Se/S ratio. CdSeS QDs were synthesised using an aqueous synthetic route thereby avoiding the use of organic reagents, high temperatures and inert gasses. The suitability of the CdSeS QDs to ECL sensing applications is demonstrated via the quantitative determination of TIMP-1 protein at clinically relevant concentrations. The developed cathodic ECL immunosensor exhibited a detectable linear range of 6–60 ng/mL and a limit of detection (LOD) of 1.54 ng/mL. TIMP-1 protein plays a crucial role in pregnancy, wound healing, and cancer prognosis.

AB - The development of electrochemiluminescent (ECL) luminophores with tuneable emission profiles is a key requirement in the development of multi-analyte ECL sensing platforms. This study presents the first reported use of cadmium selenide sulfide (CdSeS) quantum dots (QDs) as ECL emitters in which both the ECL emission profile and cathodic potential can be tailored by alteration of the Se/S ratio. CdSeS QDs were synthesised using an aqueous synthetic route thereby avoiding the use of organic reagents, high temperatures and inert gasses. The suitability of the CdSeS QDs to ECL sensing applications is demonstrated via the quantitative determination of TIMP-1 protein at clinically relevant concentrations. The developed cathodic ECL immunosensor exhibited a detectable linear range of 6–60 ng/mL and a limit of detection (LOD) of 1.54 ng/mL. TIMP-1 protein plays a crucial role in pregnancy, wound healing, and cancer prognosis.

KW - CdSeS

KW - Electrochemiluminescence

KW - Nanoparticle

KW - Point of care biosensing

KW - TIMP 1 protein

KW - Tuneable emission

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U2 - 10.1016/j.bioelechem.2022.108221

DO - 10.1016/j.bioelechem.2022.108221

M3 - Article

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AN - SCOPUS:85136051650

SN - 1567-5394

VL - 148

SP - -

JO - Bioelectrochemistry

JF - Bioelectrochemistry

M1 - 108221

ER -

Cadmium selenide sulfide quantum dots with tuneable emission profiles: An electrochemiluminescence platform for the determination of TIMP-1 protein

Abstract

Keywords

UN SDGs

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