TY - JOUR
T1 - Can brain natriuretic peptides and osteoprotegerin serve as biochemical markers for the detection of aortic pathology in children and adolescents with turner syndrome?
AU - Mavinkurve, Meenal
AU - O'Gorman, Clodagh S.
N1 - Publisher Copyright:
© 2017 Mavinkurve and O'Gorman.
PY - 2017/7/4
Y1 - 2017/7/4
N2 - Turner syndrome (TS) is a chromosomal disorder that affects 1:2,000 females. It results from either the complete or partial loss of the X chromosome as well as other aberrations. Clinical features of TS include short stature, delayed puberty, and congenital cardiac malformations. TS children also have an increased prevalence of cardiometabolic risk factors, which predisposes them to complications like coronary artery disease, cerebrovascular-related deaths, and aortic dissection. Early cardiac imaging, such as echocardiography and cardiac magnetic resonance imaging, are recommended to detect underlying aortic pathology. However, these modalities are limited by cost, accessibility, and are operator dependent. In view of these shortcomings, alternative methods, like vascular biomarkers, are currently being explored. There are only a few studies that have examined the relationship between B-type natriuretic peptide (BNP), N-terminal pro BNP (NT pro-BNP), and osteoprotegerin (OPG) and aortic disease in TS, and thus the data are only in proof-of-concept stages. Further meticulous longitudinal studies are required before BNP, NT pro-BNP, and OPG are used as vascular biomarkers for the detection of aortic disease in childhood and adolescent TS.
AB - Turner syndrome (TS) is a chromosomal disorder that affects 1:2,000 females. It results from either the complete or partial loss of the X chromosome as well as other aberrations. Clinical features of TS include short stature, delayed puberty, and congenital cardiac malformations. TS children also have an increased prevalence of cardiometabolic risk factors, which predisposes them to complications like coronary artery disease, cerebrovascular-related deaths, and aortic dissection. Early cardiac imaging, such as echocardiography and cardiac magnetic resonance imaging, are recommended to detect underlying aortic pathology. However, these modalities are limited by cost, accessibility, and are operator dependent. In view of these shortcomings, alternative methods, like vascular biomarkers, are currently being explored. There are only a few studies that have examined the relationship between B-type natriuretic peptide (BNP), N-terminal pro BNP (NT pro-BNP), and osteoprotegerin (OPG) and aortic disease in TS, and thus the data are only in proof-of-concept stages. Further meticulous longitudinal studies are required before BNP, NT pro-BNP, and OPG are used as vascular biomarkers for the detection of aortic disease in childhood and adolescent TS.
KW - B-type natriuretic peptide
KW - N-terminal pro BNP
KW - Osteoprotegrin
KW - Turner syndrome
KW - Vasculopathy
UR - http://www.scopus.com/inward/record.url?scp=85025475946&partnerID=8YFLogxK
U2 - 10.3389/fendo.2017.00142
DO - 10.3389/fendo.2017.00142
M3 - Short survey
AN - SCOPUS:85025475946
SN - 1664-2392
VL - 8
SP - 142
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
IS - JUL
M1 - 142
ER -