Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata

P. Ryan; C. Motherway; J. Powell; A. Elsaka; A. A. Sheikh; A. Jahangir; N. H. O'Connell; C. P. Dunne

doi:10.1016/j.jhin.2019.01.017

Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata

P. Ryan, C. Motherway, J. Powell, A. Elsaka, A. A. Sheikh, A. Jahangir, N. H. O'Connell, C. P. Dunne

Research output: Contribution to journal › Article › peer-review

Abstract

The cumulative incidence of candidaemia in an Irish intensive care unit (ICU) setting between January 2004 and August 2018 was 17/1000 ICU admissions. Candida albicans was responsible for 55% (N=41) of cases. C. glabrata (N=21, 28%) was the next most prevalent species, and has been identified most frequently since 2012. C. glabrata was associated with a higher mortality rate (57%) than C. albicans (29%). All isolates were susceptible to caspofungin (0.05 μg/mL). Notably, 37% of C. glabrata isolates were resistant to fluconazole, with 13% resistant to amphotericin B, highlighting the need for prudent antifungal stewardship to impede development of multi-drug-resistant C. glabrata in the ICU setting.

Original language	English
Pages (from-to)	347-350
Number of pages	4
Journal	Journal of Hospital Infection
Volume	102
Issue number	3
DOIs	https://doi.org/10.1016/j.jhin.2019.01.017
Publication status	Published - Jul 2019
Externally published	Yes

Keywords

Candida albicans
Candida glabrata
ICU
Increased
Prevalence

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10.1016/j.jhin.2019.01.017

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title = "Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata",

abstract = "The cumulative incidence of candidaemia in an Irish intensive care unit (ICU) setting between January 2004 and August 2018 was 17/1000 ICU admissions. Candida albicans was responsible for 55% (N=41) of cases. C. glabrata (N=21, 28%) was the next most prevalent species, and has been identified most frequently since 2012. C. glabrata was associated with a higher mortality rate (57%) than C. albicans (29%). All isolates were susceptible to caspofungin (0.05 μg/mL). Notably, 37% of C. glabrata isolates were resistant to fluconazole, with 13% resistant to amphotericin B, highlighting the need for prudent antifungal stewardship to impede development of multi-drug-resistant C. glabrata in the ICU setting.",

keywords = "Candida albicans, Candida glabrata, ICU, Increased, Prevalence",

author = "P. Ryan and C. Motherway and J. Powell and A. Elsaka and Sheikh, {A. A.} and A. Jahangir and O'Connell, {N. H.} and Dunne, {C. P.}",

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year = "2019",

month = jul,

doi = "10.1016/j.jhin.2019.01.017",

language = "English",

volume = "102",

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AU - Ryan, P.

AU - Motherway, C.

AU - Powell, J.

AU - Elsaka, A.

AU - Sheikh, A. A.

AU - Jahangir, A.

AU - O'Connell, N. H.

AU - Dunne, C. P.

PY - 2019/7

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AB - The cumulative incidence of candidaemia in an Irish intensive care unit (ICU) setting between January 2004 and August 2018 was 17/1000 ICU admissions. Candida albicans was responsible for 55% (N=41) of cases. C. glabrata (N=21, 28%) was the next most prevalent species, and has been identified most frequently since 2012. C. glabrata was associated with a higher mortality rate (57%) than C. albicans (29%). All isolates were susceptible to caspofungin (0.05 μg/mL). Notably, 37% of C. glabrata isolates were resistant to fluconazole, with 13% resistant to amphotericin B, highlighting the need for prudent antifungal stewardship to impede development of multi-drug-resistant C. glabrata in the ICU setting.

KW - Candida albicans

KW - Candida glabrata

KW - ICU

KW - Increased

KW - Prevalence

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ER -

Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata

Abstract

Keywords

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