Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

E. Assadpour; A. Rezaei; S.S. Das; B.V. Krishna Rao; S.K. Singh; M.S. Kharazmi; N.K. Jha; S.K. Jha; M.A. Prieto; S.M. Jafari

doi:10.3390/ph16040487

Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

E. Assadpour
, A. Rezaei
, S.S. Das
, B.V. Krishna Rao
, S.K. Singh
, M.S. Kharazmi
, N.K. Jha
, S.K. Jha
, M.A. Prieto
, S.M. Jafari

Research output: Contribution to journal › Article › peer-review

Abstract

Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD.

Original language	English
Article number	487
Number of pages	26
Journal	Pharmaceuticals
Volume	16
Issue number	4
DOIs	https://doi.org/10.3390/ph16040487
Publication status	Published - Apr 2023

Keywords

Cannabis sativa
Bioavailability
Cannabidiol
Molecular mechanism
Nanomedicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ph16040487

Cite this

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title = "Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications",

abstract = "Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD.",

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AU - Rezaei, A.

AU - Das, S.S.

AU - Krishna Rao, B.V.

AU - Singh, S.K.

AU - Kharazmi, M.S.

AU - Jha, N.K.

AU - Jha, S.K.

AU - Prieto, M.A.

AU - Jafari, S.M.

PY - 2023/4

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N2 - Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD.

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KW - Cannabis sativa

KW - Bioavailability

KW - Cannabidiol

KW - Molecular mechanism

KW - Nanomedicine

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Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

Abstract

Keywords

UN SDGs

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