TY - JOUR
T1 - Carboxylated PEG-Functionalized MnFe2O4Nanocubes Synthesized in a Mixed Solvent
T2 - Morphology, Magnetic Properties, and Biomedical Applications
AU - Kalaiselvan, Chandunika R.
AU - Thorat, Nanasaheb D.
AU - Sahu, Niroj Kumar
N1 - Publisher Copyright:
© 2021 The Authors. Published by American Chemical Society.
PY - 2021/3/2
Y1 - 2021/3/2
N2 - Ferrites are one of the most studied materials around the globe due to their distinctive biological and magnetic properties. In the same line, anisotropic MnFe2O4 nanoparticles have been explored as a potential candidate possessing excellent magnetic properties, biocompatibility, and strong magnetic resonance imaging (MRI) properties such as r2 relaxivity for magnetic field-guided biomedical applications. The current work reports the synthesis and morphological evolution of MnFe2O4 nanocubes (MNCs) in a hydrothermal process using different volume ratios of water and ethanol. The synthesis protocol was designed to influence the properties of the ferrite nanocubes, for example, the variation in surface tension, dielectric properties, and the ionic character of the solvent, and this has been achieved by adding ethanol into water during the synthesis. Pristine MnFe2O4 is formed with well-defined cubic to irregular cubic shapes with the addition of ethanol, as evidenced from XRD, field emission scanning electron microscopy, and porosity measurements. MNCs have been investigated for magnetic hyperthermia and MRI applications. Well-defined cubic-shaped MNCs with uniform size distribution possessed a high saturation magnetization of 63 emu g-1 and a transverse relaxivity (r2) of 216 mM-1 s-1 (Mn + Fe). Furthermore, the colloidal nanocubes showed concentration-dependent hyperthermic response under an alternating magnetic field. The MNCs are biocompatible but advantageously show anticancer activities on breast cancer MCF 7 and MDA-MB-231 cells.
AB - Ferrites are one of the most studied materials around the globe due to their distinctive biological and magnetic properties. In the same line, anisotropic MnFe2O4 nanoparticles have been explored as a potential candidate possessing excellent magnetic properties, biocompatibility, and strong magnetic resonance imaging (MRI) properties such as r2 relaxivity for magnetic field-guided biomedical applications. The current work reports the synthesis and morphological evolution of MnFe2O4 nanocubes (MNCs) in a hydrothermal process using different volume ratios of water and ethanol. The synthesis protocol was designed to influence the properties of the ferrite nanocubes, for example, the variation in surface tension, dielectric properties, and the ionic character of the solvent, and this has been achieved by adding ethanol into water during the synthesis. Pristine MnFe2O4 is formed with well-defined cubic to irregular cubic shapes with the addition of ethanol, as evidenced from XRD, field emission scanning electron microscopy, and porosity measurements. MNCs have been investigated for magnetic hyperthermia and MRI applications. Well-defined cubic-shaped MNCs with uniform size distribution possessed a high saturation magnetization of 63 emu g-1 and a transverse relaxivity (r2) of 216 mM-1 s-1 (Mn + Fe). Furthermore, the colloidal nanocubes showed concentration-dependent hyperthermic response under an alternating magnetic field. The MNCs are biocompatible but advantageously show anticancer activities on breast cancer MCF 7 and MDA-MB-231 cells.
UR - http://www.scopus.com/inward/record.url?scp=85102017026&partnerID=8YFLogxK
U2 - 10.1021/acsomega.0c05382
DO - 10.1021/acsomega.0c05382
M3 - Article
AN - SCOPUS:85102017026
SN - 2470-1343
VL - 6
SP - 5266
EP - 5275
JO - ACS Omega
JF - ACS Omega
IS - 8
ER -
