Caseinophosphopeptides

Alice B. Nongonierma, Richard J. FitzGerald

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Caseinophosphopeptides (CPPs) are phosphorylated peptides which are encrypted within the primary sequence of caseins. They may be released from caseins following enzymatic hydrolysis, fermentation or during gastrointestinal digestion. CPPs have generated significant interest due to their ability to bind bivalent minerals (e.g., calcium, iron, magnesium, copper and zinc) and for their potential to enhance dietary mineral bioavailability. This chapter focuses on the structure-function properties of CPPs, their production and industrial applications. The biofunctional properties of CPPs are outlined. As a result of their ability to bind bivalent minerals, CPPs have been proposed as food ingredients possessing health properties targeting various human diseases associated with mineral deficiencies (e.g., osteoporosis, dental caries and iron deficiency anemia). To date, most studies with CPPs have been conducted using in vitro methodologies, however, an increasing number of animal and human studies, more particularly in the area of dental health have been described. The health benefit outcomes of some of these studies still appear inconclusive due to a number of contradictory findings. Nevertheless, careful choice of the format/matrix in which CPPs are fed to human subjects may significantly improve their health enhancing effects.

Original languageEnglish
Title of host publicationEncyclopedia of Food Chemistry
PublisherElsevier
Pages300-312
Number of pages13
ISBN (Electronic)9780128140451
ISBN (Print)9780128140260
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Anemia
  • Bioactive peptides
  • Bioavailability
  • Calcium
  • Caseinophosphopeptides
  • Dental caries
  • Human studies
  • Iron
  • Milk proteins
  • Mineral binding
  • Osteoporosis
  • Zinc

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