Cation diffusion facilitator family: Structure and function

Olga Kolaj-Robin; David Russell; Kevin A. Hayes; J. Tony Pembroke; Tewfik Soulimane

doi:10.1016/j.febslet.2015.04.007

Cation diffusion facilitator family: Structure and function

Olga Kolaj-Robin, David Russell, Kevin A. Hayes, J. Tony Pembroke, Tewfik Soulimane

University of Limerick

Research output: Contribution to journal › Review article › peer-review

Abstract

Abstract The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins capable of transporting zinc and other heavy metal ions. Involved in metal tolerance/resistance by efflux of ions, CDF proteins share a two-modular architecture consisting of a transmembrane domain (TMD) and C-terminal domain (CTD) that protrudes into the cytoplasm. Discovery of a Zn²⁺ and Cd²⁺ CDF transporter from a marine bacterium Maricaulis maris that does not possess the CTD questions current perceptions regarding this family of proteins. This article describes a new, CTD-lacking subfamily of CDFs and our current knowledge about this family of proteins in the view of these findings.

Original language	English
Article number	37102
Pages (from-to)	1283-1295
Number of pages	13
Journal	FEBS Letters
Volume	589
Issue number	12
DOIs	https://doi.org/10.1016/j.febslet.2015.04.007
Publication status	Published - 22 May 2015

Keywords

Cation Diffusion Facilitator
Maricaulis maris
Membrane protein
Zinc transporter

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2015.04.007

Cite this

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title = "Cation diffusion facilitator family: Structure and function",

abstract = "Abstract The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins capable of transporting zinc and other heavy metal ions. Involved in metal tolerance/resistance by efflux of ions, CDF proteins share a two-modular architecture consisting of a transmembrane domain (TMD) and C-terminal domain (CTD) that protrudes into the cytoplasm. Discovery of a Zn2+ and Cd2+ CDF transporter from a marine bacterium Maricaulis maris that does not possess the CTD questions current perceptions regarding this family of proteins. This article describes a new, CTD-lacking subfamily of CDFs and our current knowledge about this family of proteins in the view of these findings.",

keywords = "Cation Diffusion Facilitator, Maricaulis maris, Membrane protein, Zinc transporter",

author = "Olga Kolaj-Robin and David Russell and Hayes, \{Kevin A.\} and Pembroke, \{J. Tony\} and Tewfik Soulimane",

note = "Publisher Copyright: {\textcopyright} 2015 Federation of European Biochemical Societies.",

year = "2015",

month = may,

day = "22",

doi = "10.1016/j.febslet.2015.04.007",

language = "English",

volume = "589",

pages = "1283--1295",

journal = "FEBS Letters",

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TY - JOUR

T1 - Cation diffusion facilitator family

T2 - Structure and function

AU - Kolaj-Robin, Olga

AU - Russell, David

AU - Hayes, Kevin A.

AU - Pembroke, J. Tony

AU - Soulimane, Tewfik

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Abstract The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins capable of transporting zinc and other heavy metal ions. Involved in metal tolerance/resistance by efflux of ions, CDF proteins share a two-modular architecture consisting of a transmembrane domain (TMD) and C-terminal domain (CTD) that protrudes into the cytoplasm. Discovery of a Zn2+ and Cd2+ CDF transporter from a marine bacterium Maricaulis maris that does not possess the CTD questions current perceptions regarding this family of proteins. This article describes a new, CTD-lacking subfamily of CDFs and our current knowledge about this family of proteins in the view of these findings.

AB - Abstract The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins capable of transporting zinc and other heavy metal ions. Involved in metal tolerance/resistance by efflux of ions, CDF proteins share a two-modular architecture consisting of a transmembrane domain (TMD) and C-terminal domain (CTD) that protrudes into the cytoplasm. Discovery of a Zn2+ and Cd2+ CDF transporter from a marine bacterium Maricaulis maris that does not possess the CTD questions current perceptions regarding this family of proteins. This article describes a new, CTD-lacking subfamily of CDFs and our current knowledge about this family of proteins in the view of these findings.

KW - Cation Diffusion Facilitator

KW - Maricaulis maris

KW - Membrane protein

KW - Zinc transporter

UR - https://www.scopus.com/pages/publications/84937763688

U2 - 10.1016/j.febslet.2015.04.007

DO - 10.1016/j.febslet.2015.04.007

M3 - Review article

C2 - 25896018

AN - SCOPUS:84937763688

SN - 0014-5793

VL - 589

SP - 1283

EP - 1295

JO - FEBS Letters

JF - FEBS Letters

IS - 12

M1 - 37102

ER -

Cation diffusion facilitator family: Structure and function

Abstract

Keywords

UN SDGs

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