TY - JOUR
T1 - CD23 expression in non‐Hodgkin lymphoma
T2 - Immunohistochemical demonstration using the antibody BU38 on paraffin sections
AU - Murray, Paul G.
AU - Janmohamed, Riaz M.I.
AU - Crocker, John
PY - 1991/10
Y1 - 1991/10
N2 - The leucocyte antigen CD23 is upregulated in the early stages of B‐cell activation by Interleukin‐4 (IL‐4), and functions as an IgE receptor and lymphocyte growth factor. We have studied the expression of CD23 in 68 cases of non‐Hodgkin lymphoma (NHL) using the antibody BU38. This new antibody has the great advantage of being applicable to routinely‐processed paraffin sections. CD23 was expressed in tumour cells in 27 out of 36 cases of low grade NHL and 3 out of 32 cases of high grade NHL. Follicular dendritic cells were strongly positive and were seen in follicular lymphomas. Macrophages were also positive and were numerous in high grade lesions.
AB - The leucocyte antigen CD23 is upregulated in the early stages of B‐cell activation by Interleukin‐4 (IL‐4), and functions as an IgE receptor and lymphocyte growth factor. We have studied the expression of CD23 in 68 cases of non‐Hodgkin lymphoma (NHL) using the antibody BU38. This new antibody has the great advantage of being applicable to routinely‐processed paraffin sections. CD23 was expressed in tumour cells in 27 out of 36 cases of low grade NHL and 3 out of 32 cases of high grade NHL. Follicular dendritic cells were strongly positive and were seen in follicular lymphomas. Macrophages were also positive and were numerous in high grade lesions.
KW - CD23
KW - immunohistochemistry
KW - non‐Hodgkin lymphomas
UR - http://www.scopus.com/inward/record.url?scp=0025954458&partnerID=8YFLogxK
U2 - 10.1002/path.1711650207
DO - 10.1002/path.1711650207
M3 - Article
C2 - 1744798
AN - SCOPUS:0025954458
SN - 0022-3417
VL - 165
SP - 125
EP - 128
JO - The Journal of Pathology
JF - The Journal of Pathology
IS - 2
ER -