Abstract
The leucocyte antigen CD23 is upregulated in the early stages of B‐cell activation by Interleukin‐4 (IL‐4), and functions as an IgE receptor and lymphocyte growth factor. We have studied the expression of CD23 in 68 cases of non‐Hodgkin lymphoma (NHL) using the antibody BU38. This new antibody has the great advantage of being applicable to routinely‐processed paraffin sections. CD23 was expressed in tumour cells in 27 out of 36 cases of low grade NHL and 3 out of 32 cases of high grade NHL. Follicular dendritic cells were strongly positive and were seen in follicular lymphomas. Macrophages were also positive and were numerous in high grade lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 125-128 |
| Number of pages | 4 |
| Journal | The Journal of Pathology |
| Volume | 165 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Oct 1991 |
| Externally published | Yes |
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This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- CD23
- immunohistochemistry
- non‐Hodgkin lymphomas
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