CHAPTER 3: Designing Multi-component Biodegradable/Biocompatible Amphiphilic Polymer Co-networks for Biomedical Applications

Arvind K. Singh Chandel; Suresh K. Jewrajka

doi:10.1039/9781788015769-00047

CHAPTER 3: Designing Multi-component Biodegradable/Biocompatible Amphiphilic Polymer Co-networks for Biomedical Applications

Arvind K. Singh Chandel
, Suresh K. Jewrajka

CSIR - Central Salt Marine Chemicals Research Institute
Academy of Scientific and Innovative Research

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This chapter presents novel, multi-component amphiphilic polymer co-networks (APCNs), which, in addition to the hydrophilic, typically poly(ethylene glycol) or poly[(2-dimethylamino)ethyl methacrylate], and hydrophobic, typically poly(?-caprolactone), polymeric components, a hydrophilic polysaccharide is also incorporated. These polysaccharides are agarose and dextran. The biocompatibility and biodegradability of the APCNs are investigated, as well as their drug loading capacity and release behaviour. The results indicate that the present APCNs represent excellent choices as materials for biomedical applications. Furthermore, this chapter compares the properties of common polymeric hydrogels with those of amphiphilic polymer co-networks, and provides our vision regarding the potential of degradable APCNs in biomedical applications.

Original language	English
Title of host publication	Synthetic Polymer Chemistry
Subtitle of host publication	Innovations and Outlook
Publisher	Royal Society of Chemistry
Pages	47-76
Number of pages	30
Edition	33
DOIs	https://doi.org/10.1039/9781788015769-00047
Publication status	Published - 2020
Externally published	Yes

Publication series

Name	RSC Polymer Chemistry Series
Number	33
Volume	2020-January
ISSN (Print)	2044-0790
ISSN (Electronic)	2044-0804

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10.1039/9781788015769-00047

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Singh Chandel, A. K., & Jewrajka, S. K. (2020). CHAPTER 3: Designing Multi-component Biodegradable/Biocompatible Amphiphilic Polymer Co-networks for Biomedical Applications. In Synthetic Polymer Chemistry: Innovations and Outlook (33 ed., pp. 47-76). (RSC Polymer Chemistry Series; Vol. 2020-January, No. 33). Royal Society of Chemistry. https://doi.org/10.1039/9781788015769-00047

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title = "CHAPTER 3: Designing Multi-component Biodegradable/Biocompatible Amphiphilic Polymer Co-networks for Biomedical Applications",

abstract = "This chapter presents novel, multi-component amphiphilic polymer co-networks (APCNs), which, in addition to the hydrophilic, typically poly(ethylene glycol) or poly[(2-dimethylamino)ethyl methacrylate], and hydrophobic, typically poly(?-caprolactone), polymeric components, a hydrophilic polysaccharide is also incorporated. These polysaccharides are agarose and dextran. The biocompatibility and biodegradability of the APCNs are investigated, as well as their drug loading capacity and release behaviour. The results indicate that the present APCNs represent excellent choices as materials for biomedical applications. Furthermore, this chapter compares the properties of common polymeric hydrogels with those of amphiphilic polymer co-networks, and provides our vision regarding the potential of degradable APCNs in biomedical applications.",

author = "\{Singh Chandel\}, \{Arvind K.\} and Jewrajka, \{Suresh K.\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2020.",

year = "2020",

doi = "10.1039/9781788015769-00047",

language = "English",

series = "RSC Polymer Chemistry Series",

publisher = "Royal Society of Chemistry",

number = "33",

pages = "47--76",

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}

CHAPTER 3: Designing Multi-component Biodegradable/Biocompatible Amphiphilic Polymer Co-networks for Biomedical Applications. / Singh Chandel, Arvind K.; Jewrajka, Suresh K.
Synthetic Polymer Chemistry: Innovations and Outlook. 33. ed. Royal Society of Chemistry, 2020. p. 47-76 (RSC Polymer Chemistry Series; Vol. 2020-January, No. 33).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AB - This chapter presents novel, multi-component amphiphilic polymer co-networks (APCNs), which, in addition to the hydrophilic, typically poly(ethylene glycol) or poly[(2-dimethylamino)ethyl methacrylate], and hydrophobic, typically poly(?-caprolactone), polymeric components, a hydrophilic polysaccharide is also incorporated. These polysaccharides are agarose and dextran. The biocompatibility and biodegradability of the APCNs are investigated, as well as their drug loading capacity and release behaviour. The results indicate that the present APCNs represent excellent choices as materials for biomedical applications. Furthermore, this chapter compares the properties of common polymeric hydrogels with those of amphiphilic polymer co-networks, and provides our vision regarding the potential of degradable APCNs in biomedical applications.

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CHAPTER 3: Designing Multi-component Biodegradable/Biocompatible Amphiphilic Polymer Co-networks for Biomedical Applications

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