@inbook{dc6337e8e0ec453e83c9a402784d9313,
title = "Chapter 5.2 The use of microdialysis in neuropsychiatric disease models",
abstract = "This review describes the recent use of microdialysis in several neuropsychiatric disease models including schizophrenia, stress, addiction and depression and demonstrates the ability of this tool to target neurotransmitter systems and brain regions implicated in psychiatric illness. Microdialysis studies in psychotropic drug induced, neurodevelopmental and the more recently evolving 'connectivity' models are mentioned with particular emphasis on animal models of schizophrenia. The use of microdialysis as a drug delivery tool in neuropsychiatric disease models is also addressed and is of particular value in designing disease-modifying therapies focused on modulating structural and behavioural endophenotypes by targeting specific neurotransmitter systems and genes. The validity of animal models including how animal models constitute theories about disorders is also addressed.",
author = "O'Connor, {William T.}",
year = "2006",
doi = "10.1016/S1569-7339(06)16022-1",
language = "English",
isbn = "9780444522764",
series = "Handbook of Behavioral Neuroscience",
pages = "419--434",
editor = "Ben Westerink and Thomas Cremers",
booktitle = "Handbook of Microdialysis Methods, Applications and Perspectives",
}