Characterisation of bioactive polycaprolactone

P. Douglas, G. Walker, D. Jones

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The effects of a bioactive [Nalidixic Acid - NA] and copolymers [Poly L-Lactic Acid (PLLA) and Polyethylene Glycol (PEG)] on the drug release, morphology and mechanical properties of Poly ε-caprolactone [PCL] were studied. Release of NA increased with the addition of copolymers in the PCL, with a maximum release of 55% in a blend containing 5%w/w each of PLLA, PEG and NA. The filler effect of the NA was illustrated by an increase in viscosity in the blends. FTIR spectrums showed the blending of the PCL and the NA. The carbonyl bond present in the biodegradable polymers PCL and PEG allowed for some degree of miscibility, also confirmed by the decrease in thermal conductivity from 0.26 to 0.2 Wm- 1°C. Mechanical properties were decreased by the copolymers, with the Young's Modulus decreasing by 15%.

Original languageEnglish
Title of host publicationSociety of Plastics Engineers - 66th Annual Technical Conference of the Society of Plastics Engineers, Plastics Encounter at ANTEC 2008
Pages518-522
Number of pages5
Publication statusPublished - 2008
Externally publishedYes
Event66th Annual Technical Conference of the Society of Plastics Engineers, Plastics Encounter at ANTEC 2008 - Milwaukee, WI, United States
Duration: 4 May 20088 May 2008

Publication series

NameTechnical Papers, Regional Technical Conference - Society of Plastics Engineers
Volume1

Conference

Conference66th Annual Technical Conference of the Society of Plastics Engineers, Plastics Encounter at ANTEC 2008
Country/TerritoryUnited States
CityMilwaukee, WI
Period4/05/088/05/08

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