TY - GEN
T1 - Characterisation of bioactive polycaprolactone
AU - Douglas, P.
AU - Walker, G.
AU - Jones, D.
PY - 2008
Y1 - 2008
N2 - The effects of a bioactive [Nalidixic Acid - NA] and copolymers [Poly L-Lactic Acid (PLLA) and Polyethylene Glycol (PEG)] on the drug release, morphology and mechanical properties of Poly ε-caprolactone [PCL] were studied. Release of NA increased with the addition of copolymers in the PCL, with a maximum release of 55% in a blend containing 5%w/w each of PLLA, PEG and NA. The filler effect of the NA was illustrated by an increase in viscosity in the blends. FTIR spectrums showed the blending of the PCL and the NA. The carbonyl bond present in the biodegradable polymers PCL and PEG allowed for some degree of miscibility, also confirmed by the decrease in thermal conductivity from 0.26 to 0.2 Wm- 1°C. Mechanical properties were decreased by the copolymers, with the Young's Modulus decreasing by 15%.
AB - The effects of a bioactive [Nalidixic Acid - NA] and copolymers [Poly L-Lactic Acid (PLLA) and Polyethylene Glycol (PEG)] on the drug release, morphology and mechanical properties of Poly ε-caprolactone [PCL] were studied. Release of NA increased with the addition of copolymers in the PCL, with a maximum release of 55% in a blend containing 5%w/w each of PLLA, PEG and NA. The filler effect of the NA was illustrated by an increase in viscosity in the blends. FTIR spectrums showed the blending of the PCL and the NA. The carbonyl bond present in the biodegradable polymers PCL and PEG allowed for some degree of miscibility, also confirmed by the decrease in thermal conductivity from 0.26 to 0.2 Wm- 1°C. Mechanical properties were decreased by the copolymers, with the Young's Modulus decreasing by 15%.
UR - http://www.scopus.com/inward/record.url?scp=52349103138&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:52349103138
SN - 9781605603209
T3 - Technical Papers, Regional Technical Conference - Society of Plastics Engineers
SP - 518
EP - 522
BT - Society of Plastics Engineers - 66th Annual Technical Conference of the Society of Plastics Engineers, Plastics Encounter at ANTEC 2008
T2 - 66th Annual Technical Conference of the Society of Plastics Engineers, Plastics Encounter at ANTEC 2008
Y2 - 4 May 2008 through 8 May 2008
ER -