Characterization of paracetamol agglomerates by image analysis and strength measurement

Eva M. Ålander; Marketta S. Uusi-Penttilä; Åke C. Rasmuson

doi:10.1016/S0032-5910(02)00208-5

Characterization of paracetamol agglomerates by image analysis and strength measurement

Eva M. Ålander, Marketta S. Uusi-Penttilä, Åke C. Rasmuson

KTH Royal Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Paracetamol is crystallized in different solvents and techniques are developed and used to characterize the product. The product particles from three different solvent compositions: ethylene glycol, acetone and an acetone-water mixture (30-70 wt.%) have been examined. Product properties visually observed are quantified by image analysis and evaluation of measured image descriptors with Principal Component Analysis (PCA). The agglomerate strength has been determined by crushing single agglomerates. Depending on the solvent, the content of single crystals and agglomerates differ. Agglomerates differ by the number and size of crystals grown together, as well as by the strength.

Original language	English
Pages (from-to)	298-306
Number of pages	9
Journal	Powder Technology
Volume	130
Issue number	1-3
DOIs	https://doi.org/10.1016/S0032-5910(02)00208-5
Publication status	Published - 19 Feb 2003
Externally published	Yes

Keywords

Agglomeration
Crushing strength
Crystallization
Image analysis
PCA

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10.1016/S0032-5910(02)00208-5

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title = "Characterization of paracetamol agglomerates by image analysis and strength measurement",

abstract = "Paracetamol is crystallized in different solvents and techniques are developed and used to characterize the product. The product particles from three different solvent compositions: ethylene glycol, acetone and an acetone-water mixture (30-70 wt.%) have been examined. Product properties visually observed are quantified by image analysis and evaluation of measured image descriptors with Principal Component Analysis (PCA). The agglomerate strength has been determined by crushing single agglomerates. Depending on the solvent, the content of single crystals and agglomerates differ. Agglomerates differ by the number and size of crystals grown together, as well as by the strength.",

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AU - Ålander, Eva M.

AU - Uusi-Penttilä, Marketta S.

AU - Rasmuson, Åke C.

PY - 2003/2/19

Y1 - 2003/2/19

N2 - Paracetamol is crystallized in different solvents and techniques are developed and used to characterize the product. The product particles from three different solvent compositions: ethylene glycol, acetone and an acetone-water mixture (30-70 wt.%) have been examined. Product properties visually observed are quantified by image analysis and evaluation of measured image descriptors with Principal Component Analysis (PCA). The agglomerate strength has been determined by crushing single agglomerates. Depending on the solvent, the content of single crystals and agglomerates differ. Agglomerates differ by the number and size of crystals grown together, as well as by the strength.

AB - Paracetamol is crystallized in different solvents and techniques are developed and used to characterize the product. The product particles from three different solvent compositions: ethylene glycol, acetone and an acetone-water mixture (30-70 wt.%) have been examined. Product properties visually observed are quantified by image analysis and evaluation of measured image descriptors with Principal Component Analysis (PCA). The agglomerate strength has been determined by crushing single agglomerates. Depending on the solvent, the content of single crystals and agglomerates differ. Agglomerates differ by the number and size of crystals grown together, as well as by the strength.

KW - Agglomeration

KW - Crushing strength

KW - Crystallization

KW - Image analysis

KW - PCA

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DO - 10.1016/S0032-5910(02)00208-5

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AN - SCOPUS:0037453887

SN - 0032-5910

VL - 130

SP - 298

EP - 306

JO - Powder Technology

JF - Powder Technology

IS - 1-3

ER -

Characterization of paracetamol agglomerates by image analysis and strength measurement

Abstract

Keywords

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