TY - JOUR
T1 - Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens
T2 - Biochemical and functional correlates
AU - Tanganelli, Sergio
AU - Fuxe, Kjell
AU - Antonelli, Tiziana
AU - O'Connor, William Thomas
AU - Ferraro, Luca
PY - 2001
Y1 - 2001
N2 - The present article reviews our recent biochemical and microdialysis studies showing the evidence for an antagonistic CCKB/D2 receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and GABAergic transmission in the ipsilateral ventral pallidum. Since the nucleus accumbens plays a crucial role in regulating the output from the limbic system and consequently motivation, it may be speculated that a dysregulation of this receptor interaction may have consequences in a wide range of central nervous system disorders.
AB - The present article reviews our recent biochemical and microdialysis studies showing the evidence for an antagonistic CCKB/D2 receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and GABAergic transmission in the ipsilateral ventral pallidum. Since the nucleus accumbens plays a crucial role in regulating the output from the limbic system and consequently motivation, it may be speculated that a dysregulation of this receptor interaction may have consequences in a wide range of central nervous system disorders.
KW - Binding
KW - Cholecystokinin agonists and antagonists
KW - Microdialysis
KW - Motivation and central nervous system disorders
KW - Receptor-receptor interactions
UR - http://www.scopus.com/inward/record.url?scp=0034908119&partnerID=8YFLogxK
U2 - 10.1016/S0196-9781(01)00446-6
DO - 10.1016/S0196-9781(01)00446-6
M3 - Review article
C2 - 11457515
AN - SCOPUS:0034908119
SN - 0196-9781
VL - 22
SP - 1229
EP - 1234
JO - Peptides
JF - Peptides
IS - 8
ER -