Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: Biochemical and functional correlates

Sergio Tanganelli; Kjell Fuxe; Tiziana Antonelli; William Thomas O'Connor; Luca Ferraro

doi:10.1016/S0196-9781(01)00446-6

Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: Biochemical and functional correlates

Sergio Tanganelli, Kjell Fuxe, Tiziana Antonelli, William Thomas O'Connor, Luca Ferraro

Research output: Contribution to journal › Review article › peer-review

Abstract

The present article reviews our recent biochemical and microdialysis studies showing the evidence for an antagonistic CCK_B/D₂ receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and GABAergic transmission in the ipsilateral ventral pallidum. Since the nucleus accumbens plays a crucial role in regulating the output from the limbic system and consequently motivation, it may be speculated that a dysregulation of this receptor interaction may have consequences in a wide range of central nervous system disorders.

Original language	English
Pages (from-to)	1229-1234
Number of pages	6
Journal	Peptides
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/S0196-9781(01)00446-6
Publication status	Published - 2001
Externally published	Yes

Keywords

Binding
Cholecystokinin agonists and antagonists
Microdialysis
Motivation and central nervous system disorders
Receptor-receptor interactions

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10.1016/S0196-9781(01)00446-6

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title = "Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: Biochemical and functional correlates",

abstract = "The present article reviews our recent biochemical and microdialysis studies showing the evidence for an antagonistic CCKB/D2 receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and GABAergic transmission in the ipsilateral ventral pallidum. Since the nucleus accumbens plays a crucial role in regulating the output from the limbic system and consequently motivation, it may be speculated that a dysregulation of this receptor interaction may have consequences in a wide range of central nervous system disorders.",

keywords = "Binding, Cholecystokinin agonists and antagonists, Microdialysis, Motivation and central nervous system disorders, Receptor-receptor interactions",

author = "Sergio Tanganelli and Kjell Fuxe and Tiziana Antonelli and O'Connor, \{William Thomas\} and Luca Ferraro",

year = "2001",

doi = "10.1016/S0196-9781(01)00446-6",

language = "English",

volume = "22",

pages = "1229--1234",

journal = "Peptides",

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T1 - Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens

T2 - Biochemical and functional correlates

AU - Tanganelli, Sergio

AU - Fuxe, Kjell

AU - Antonelli, Tiziana

AU - O'Connor, William Thomas

AU - Ferraro, Luca

PY - 2001

Y1 - 2001

N2 - The present article reviews our recent biochemical and microdialysis studies showing the evidence for an antagonistic CCKB/D2 receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and GABAergic transmission in the ipsilateral ventral pallidum. Since the nucleus accumbens plays a crucial role in regulating the output from the limbic system and consequently motivation, it may be speculated that a dysregulation of this receptor interaction may have consequences in a wide range of central nervous system disorders.

AB - The present article reviews our recent biochemical and microdialysis studies showing the evidence for an antagonistic CCKB/D2 receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and GABAergic transmission in the ipsilateral ventral pallidum. Since the nucleus accumbens plays a crucial role in regulating the output from the limbic system and consequently motivation, it may be speculated that a dysregulation of this receptor interaction may have consequences in a wide range of central nervous system disorders.

KW - Binding

KW - Cholecystokinin agonists and antagonists

KW - Microdialysis

KW - Motivation and central nervous system disorders

KW - Receptor-receptor interactions

UR - https://www.scopus.com/pages/publications/0034908119

U2 - 10.1016/S0196-9781(01)00446-6

DO - 10.1016/S0196-9781(01)00446-6

M3 - Review article

C2 - 11457515

AN - SCOPUS:0034908119

SN - 0196-9781

VL - 22

SP - 1229

EP - 1234

JO - Peptides

JF - Peptides

IS - 8

ER -

Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: Biochemical and functional correlates

Abstract

Keywords

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